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Modular network of marmoset PFC connection

Research Project

Project/Area Number 16K07036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Watakabe Akiya  国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (40290910)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsトレーサー / AAV / マーモセット / 大脳皮質 / 神経ネットワーク / コネクトーム / 神経解剖学 / マッピング / 霊長類 / ウイルスベクター / 前頭葉
Outline of Final Research Achievements

Prefrontal cortex (PFC) is a brain region that developed well in primate lineages. Its expansion and qualitative changes enabled high cognitive functions of humans. The specific aim of this research is to clarify the modular connectivity of the corticocortical network, which I think is the key to understand PFC. Marmoset monkey was chosen as a model primate for neuroanatomical studies using viral tracers and serial two photon tomography, which achieved efficient whole brain imaging. Combined with histological techniques, the connectional properties of remote areas are being explored. For example, area 8aD receives inputs from the contralateral PFC and ipsilateral cingular area, but those inputs are separated as columnar modules. Such modular connectivity is considered to be a general property of PFC.

Academic Significance and Societal Importance of the Research Achievements

神経科学の一大目標はヒトの脳とその疾患を理解することである。現在、神経科学研究はマウスを使った研究が圧倒的に進んでいるが、そこから得られた知見がどの程度ヒトにあてはまるのかは、実は未知数である。実際、マウスを使った創薬が失敗する例も多い。私の研究は、ある意味でマウスとヒトをつなぐことを目指している。ヒトの脳はもちろんサルとも違うが、マウスよりは明らかに共通性が多い。マウス-サル-ヒトと、進化的な考察を加えることで、共通のルールと種を分けた違いを明らかにすれば、ヒト脳に対する理解はより深まる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] PAT?Probabilistic Axon Tracking for Densely Labeled Neurons in Large 3-D Micrographs2019

    • Author(s)
      Skibbe Henrik、Reisert Marco、Nakae Ken、Watakabe Akiya、Hata Junichi、Mizukami Hiroaki、Okano Hideyuki、Yamamori Tetsuo、Ishii Shin
    • Journal Title

      IEEE Transactions on Medical Imaging

      Volume: 38 Issue: 1 Pages: 69-78

    • DOI

      10.1109/tmi.2018.2855736

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks2018

    • Author(s)
      Ebina T, Masamizu Y, Tanaka YR, Watakabe A, Hirakawa R, Hirayama Y, Hira R, Terada S, Koketsu D, Hikosaka K, Mizukami H, Nambu A, Sasaki E, Yamamori Y, Matsuzaki M
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 1879-1879

    • DOI

      10.1038/s41467-018-04286-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical networks of the mouse brain elaborate within the gray matter2018

    • Author(s)
      Watakabe Akiya、Hirokawa Junya
    • Journal Title

      Brain Structure and Function

      Volume: 223 Issue: 8 Pages: 3633-3652

    • DOI

      10.1007/s00429-018-1710-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys2018

    • Author(s)
      Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, *Ushiba J, *Okano H
    • Journal Title

      Cell Rep

      Volume: 24(8) Issue: 8 Pages: 2191-2195

    • DOI

      10.1016/j.celrep.2018.07.057

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The relationship between the claustrum and endopiriform nucleus: A perspective towards consensus on cross-species homology2018

    • Author(s)
      Smith Jared B.、Alloway Kevin D.、Hof Patrick R.、Orman Rena、Reser David H.、Watakabe Akiya、Watson Glenn D. R.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 527 Issue: 2 Pages: 476-499

    • DOI

      10.1002/cne.24537

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Axonal Projections From the Middle Temporal Area in the Common Marmoset2018

    • Author(s)
      Hiroshi Abe, Toshiki Tani, Hiromi Mashiko, Naohito Kitamura, Taku Hayami, Satoshi Watanabe, Kazuhisa Sakai, Wataru Suzuki, Hiroaki Mizukami, Akiya Watakabe, Tetsuo Yamamori and Noritaka Ichinohe
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 12 Pages: 89-89

    • DOI

      10.3389/fnana.2018.00089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-cell bioluminescence imaging of deep tissue in freely moving animals.2018

    • Author(s)
      Iwano S, Sugiyama M, Hama H, Watakabe A, Hasegawa N, Kuchimaru T, Tanaka KZ, Takahashi M, Ishida Y, Hata J, Shimozono S, Namiki K, Fukano T, Kiyama M, Okano H, Kizaka-Kondoh S, McHugh TJ, Yamamori T, Hioki H, Maki S, Miyawaki A.
    • Journal Title

      Science

      Volume: 359 Issue: 6378 Pages: 935-939

    • DOI

      10.1126/science.aaq1067

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 3D reconstruction of brain section images for creating axonal projection maps in marmosets.2017

    • Author(s)
      Abe H, Tani T, Mashiko H, Kitamura N, Miyakawa N, Mimura K, Sakai K, Suzuki W, Kurotani T, Mizukami H, Watakabe A, Yamamori T, Ichinohe N.
    • Journal Title

      J Neurosci Methods

      Volume: 286 Pages: 102-113

    • DOI

      10.1016/j.jneumeth.2017.04.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In situ hybridization analyses of claustrum-enriched genes in marmosets.2016

    • Author(s)
      Watakabe A.
    • Journal Title

      J Comp Neurol

      Volume: x Issue: 6 Pages: 1442-1458

    • DOI

      10.1002/cne.24021

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Mapping prefrontal connectivity of the common marmosets2019

    • Author(s)
      Akiya Watakabe, Henrik Skibbe, Ken Nakae, Jian Wang1, Masafumi Takaji, Alexander Woodward, Junichi Hata4, Hideyuki Okano, Yoko Yamaguchi, Shin Ishii, Hiroaki Mizukami, Tetsuo Yamamori
    • Organizer
      革新脳国際シンポジウムISBM2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mapping prefrontal connectivity of the common marmosets2019

    • Author(s)
      Akiya Watakabe, Henrik Skibbe, Ken Nakae, Jian Wang1, Masafumi Takaji, Alexander Woodward, Junichi Hata4, Hideyuki Okano, Yoko Yamaguchi, Shin Ishii, Hiroaki Mizukami, Tetsuo Yamamori
    • Organizer
      第8回マーモセット研究会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prefrontal projection mapping of the marmoset2018

    • Author(s)
      Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Henrik Skibbe, Ken Nakae, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prefrontal projection mapping of the marmoset2018

    • Author(s)
      Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Henrik Skibbe, Ken Nakae, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
    • Organizer
      SfN 2018 北米神経科学学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Columnar and diffuse connectivity of the marmoset PFC neurons2017

    • Author(s)
      Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Takashi Kawase, Henrik Skibbe, Ken Nakae, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
    • Organizer
      北米神経学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Marmoset prefrontal projection mapping by serial two-photon tomography2016

    • Author(s)
      Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Takashi Kawase, Henrik Skibbe, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
    • Organizer
      日本マーモセット学会
    • Place of Presentation
      東京大学農学部弥生講堂(東京都文京区)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Mapping connectivity of marmoset prefrontal cortex by serial two-photon tomography2016

    • Author(s)
      Akiya Watakabe, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Takashi Kawase, Henrik Skibbe, Yoko Yamaguchi, Shin Ishii, Tetsuo Yamamori
    • Organizer
      北米神経学会
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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