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The elucidation of molecular pathological condition in prion disease: analysis of interferon system to develop novel therapeutic method

Research Project

Project/Area Number 16K07042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNagasaki University

Principal Investigator

ISHIBASHI Daisuke  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (10432973)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsプリオン / 自然免疫 / インターフェロン / I型インターフェロン受容体 / IRF3 / 脳神経疾患
Outline of Final Research Achievements

In this study, we investigated a relationship of between type I interferon in innate immune responses and prion infection to host. As a result, we defined that innate immune system mediating type I interferon receptor might negatively regulate prion invasion to host. In the future, we believe that our project will be promoted development of prevention and drug for prion disease.

Academic Significance and Societal Importance of the Research Achievements

これまで注目されてこなかった自然免疫機構を視点としたプリオン感染病態メカニズムの解明について研究を遂行することにより、治療法がないプリオン病の創薬開発が進むことが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC2017

    • Author(s)
      Sano Kazunori、Atarashi Ryuichiro、Satoh Katsuya、Ishibashi Daisuke、Nakagaki Takehiro、Iwasaki Yasushi、Yoshida Mari、Murayama Shigeo、Mishima Kenichi、Nishida Noriyuki
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 5 Pages: 3916-3930

    • DOI

      10.1007/s12035-017-0624-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure-based drug discovery for combating influenza virus by targeting the PA?PB1 interaction2017

    • Author(s)
      Watanabe Ken、Ishikawa Takeshi、Otaki Hiroki、Mizuta Satoshi、Hamada Tsuyoshi、Nakagaki Takehiro、Ishibashi Daisuke、Urata Shuzo、Yasuda Jiro、Tanaka Yoshimasa、Nishida Noriyuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 9500-9500

    • DOI

      10.1038/s41598-017-10021-w

    • NAID

      120006987424

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.2016

    • Author(s)
      Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 24993-24993

    • DOI

      10.1038/srep24993

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation.2016

    • Author(s)
      Ishibashi D, Nakagaki T, Ishikawa T, Atarashi R, Watanabe K, Cruz FA, Hamada T, Nishida N.
    • Journal Title

      EBioMedicine.

      Volume: 9 Pages: 238-249

    • DOI

      10.1016/j.ebiom.2016.06.010

    • NAID

      120006987627

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] プリオン病におけるインシリコ創薬開発2018

    • Author(s)
      石橋大輔
    • Organizer
      第8回認知症研究を知る若手研究者の集まり2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] in silicoプリオン病創薬における薬効特異性の評価2018

    • Author(s)
      石橋大輔、中垣岳大、石川岳志、水田賢志、濱田剛、西田教行
    • Organizer
      生体機能と創薬シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] インフルエンザウイルス複製を標的とした蛋白質-蛋白質相互作用阻害剤の開発2018

    • Author(s)
      渡邊健, Juliann Nzembi Makau, 石川岳志, 大滝大樹, 水田賢志, 中垣岳大, 石橋大輔, 浦田秀造, 安田二朗, 西田教行
    • Organizer
      第71回 日本細菌学会九州支部総会・第55回 日本ウイルス学会九州支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 炭酸水素カルシウムメゾ構造体によるプリオン不活性化能の検討2018

    • Author(s)
      中垣岳大, 的場苑子, 石橋大輔, 西田教行
    • Organizer
      第71回 日本細菌学会九州支部総会・第55回 日本ウイルス学会九州支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] I型インターフェロンのプリオン感染に対する抑制作用 Type I interferon suppresses prion infection2018

    • Author(s)
      石橋大輔, 中垣岳大, 西田教行
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prion-like propagation of filamentous tau inclusions in cultured neuronal cells2018

    • Author(s)
      Gen Matsumoto, Naruhiko Sahara, Daisuke Ishibashi, Noriyuki Nishida, Nozomu Mori
    • Organizer
      Asian pacific prion symposium 2018 (APPS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プリオン感染における自然免疫機構の役割 Protective role of host innate immunity system in prion pathogenesis2018

    • Author(s)
      Daisuke Ishibashi, Takujiro Homma, Takehiro Nakagaki, Kazunori Sano, Kenya Honda, Ryuichiro Atarashi, Noriyuki Nishida
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] プリオン病におけるインシリコ創薬開発2017

    • Author(s)
      石橋大輔、石川岳志、中垣岳大、丹下寛也、西田教行
    • Organizer
      第70回日本細菌学会九州支部総会、第54回日本ウイルス学会九州支部総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Evaluation of drug specificity for anti-prion compounds selective by structure-based binding simulation in silico プリオン病創薬における薬効特異性の評価2017

    • Author(s)
      Daisuke Ishibashi, Takehiro Nakagaki, Takeshi Ishikawa, Tsuyoshi Hamada, Noriyuki Nishida
    • Organizer
      2017年度生命科学系学会合同年次大会 (ConBio2017), 第40回日本分子生物学会年会, 第90回日本生化学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Wire-QuIC reaction can detect abnormal human prion seeds from contaminated stainless steel-wire. Wire-QuICはステンレススチールワイヤー上に付着したプリオンを検出できる2016

    • Author(s)
      Tsuyoshi Mori, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Noriyuki Nishida
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Structure-based drug discovery for prion disease by using a novel binding simulation on the graphics processing unit intensive supercomputer2016

    • Author(s)
      Daisuke Ishibashi, Takehiro Nakagaki, Takeshi Ishikawa, Ryuichiro Atarashi, Tsuyoshi Hamada, Noriyuki Nishida
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Prion strain-dependent effect of macroautophagy on abnormal prion protein degradation2016

    • Author(s)
      Daisuke Ishibashi, Takehiro Nakagaki, Ryuichiro Atarashi, Noriyuki Nishida
    • Organizer
      Prion2016 & APPS2016
    • Place of Presentation
      日本教育会館・一橋ホール(東京都・千代田区)
    • Year and Date
      2016-05-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wire-QuIC: A new detection system of human prion2016

    • Author(s)
      Tsuyoshi Mori, Ryuichiro Atarashi, Hanae Takatsuki, Katsuya Satoh, Takehiro Nakagaki, Daisuke Ishibashi, Noriyuki Nishida
    • Organizer
      Prion2016 & APPS2016
    • Place of Presentation
      日本教育会館・一橋ホール(東京都・千代田区)
    • Year and Date
      2016-05-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] プリオン病治療薬2018

    • Inventor(s)
      石橋大輔、西田教行、水田賢志、石川岳志
    • Industrial Property Rights Holder
      国立大学法人長崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-177224
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] プリオン病予防・治療剤2016

    • Inventor(s)
      石橋大輔、西田教行、中垣岳大、濱田剛、石川岳志
    • Industrial Property Rights Holder
      石橋大輔、西田教行、中垣岳大、濱田剛、石川岳志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-170349
    • Filing Date
      2016-08-31
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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