The elucidation of molecular pathological condition in prion disease: analysis of interferon system to develop novel therapeutic method
| Project/Area Number |
16K07042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nagasaki University |
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Principal Investigator |
ISHIBASHI Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (10432973)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | プリオン / 自然免疫 / インターフェロン / I型インターフェロン受容体 / IRF3 / 脳神経疾患 |
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| Outline of Final Research Achievements |
In this study, we investigated a relationship of between type I interferon in innate immune responses and prion infection to host. As a result, we defined that innate immune system mediating type I interferon receptor might negatively regulate prion invasion to host. In the future, we believe that our project will be promoted development of prevention and drug for prion disease.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで注目されてこなかった自然免疫機構を視点としたプリオン感染病態メカニズムの解明について研究を遂行することにより、治療法がないプリオン病の創薬開発が進むことが期待される。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.2016
Author(s)
Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 24993-24993
DOI
Related Report
Peer Reviewed / Open Access
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