Analysis of neuronal function on energy metabolism in brain of alcoholism
| Project/Area Number |
16K07070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アルコール / 依存症 / mTOR / EtOH / ガラクトース / Ethanol / 神経可塑性 / 神経科学 / 脳神経疾患 / シグナル伝達 / 脂質 / 薬理学 |
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| Outline of Final Research Achievements |
Chronic consumption of ethanol has been reported to modify several molecular events in the central nervous system. In this study, chronic treatment with ethanol changes the activity of dopaminergic system containing mTOR, which is projecting from the ventral tegmental area to the nucleus accumbens as rewarding system. It is suggested that mTOR regulated by ethanol changes protein synthesis in the brain and causes addiction with synaptic plastisity.
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| Academic Significance and Societal Importance of the Research Achievements |
依存症は薬で完全に治すことが難しい病気である。未だに依存症の病態は不明な点が多く、これが治療薬開発を遅らせている原因ともなっている。本研究結果は、様々な依存症で指摘されているドパミン神経系のアルコール依存症への関与を明らかにし、さらにmTORとよばれるエネルギー代謝に深く関わる因子を含むドパミン神経をアルコールが特異的に活性化させ、依存症発現に関与する可能性を示唆する結果であり、依存症の脳機能変化の一端を明らかにするとともに依存症治療薬開発の基盤になるものと考えている。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.2018
Author(s)
Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T, Yamanaka A, Narita M.
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Journal Title
Biochem Biophys Res Commun.
Volume: 496
Issue: 4
Pages: 1102-1108
DOI
Related Report
Peer Reviewed
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[Journal Article] Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction.2018
Author(s)
Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M.
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Journal Title
Mol Brain.
Volume: 11
Issue: 1
Pages: 6-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in the expression of IL-6-mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice.2015
Author(s)
Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M.
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Journal Title
Synapse
Volume: なし
Issue: 8
Pages: 21902-21902
DOI
Related Report
Peer Reviewed / Open Access
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