Elucidation of etiology of age-related cataracts by using Cpox mutant mouse strains

Research Project

Project/Area Number	16K07086
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Laboratory animal science
Research Institution	Shinshu University
Principal Investigator	Mori Masayuki 信州大学, 学術研究院医学系, 准教授 (60273190)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	白内障 / 遺伝子 / マウス / ポルフィリン症 / 小胞体ストレス / 細胞間結合分子 / コンジェニック系マウス / ポルフィリン代謝
Outline of Final Research Achievements	By using mouse strains that share the mutant coproporphyrinogen oxidase gene but have distinct genetic background, importance of endoplasmic reticulum stress response pathway and cell adhesion molecules (gap junction protein, alpha, periplakin, periplakin, and armadillo repeat gene deleted in velocardiofacial syndrome) to development and time of onset of cataracts was revealed.
Academic Significance and Societal Importance of the Research Achievements	高齢者の多くに認められ、生活の質を大きく低下させる一因となっているにもかかわらず未だ不明な点が多い加齢性白内障の発症機序・経路の一端として小胞体ストレス反応、および細胞間結合タンパク質を明らかとすることができた。これらの経路を標的とした加齢性白内障の治療・予防の開発に新たな方向性を示すことができた。