Identification of a dormant cancer stem cell-related gene

• Project/Area Number: 16K07132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Tamai Keiichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
• Co-Investigator(Kenkyū-buntansha): 三浦 康 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (40282074)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癌幹細胞 / 胆管癌 / 胆道癌 / がん幹細胞

Outline of Final Research Achievements

We tried to identify the molecular mechanisms of cancer stem cells in cholangiocarcinoma. We identified several molecules which required for the maintenance of cancer stem cells. Our data demonstrated the possible therapeutic approach which transform the cancer stem cells into the non-cancer stem cells.

Academic Significance and Societal Importance of the Research Achievements

本研究は胆管癌の新たな治療標的を見いだした点で社会的意義が高い。

Research Products

• [Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism. (2017)
  • Author(s): Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
  • Journal Title: Cancer Science Volume: 印刷中 Issue: 5 Pages: 931-940
  • DOI: 10.1111/cas.13211
  • Peer Reviewed / Open Access
• [Journal Article] Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. (2017)
  • Author(s): Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K.
  • Journal Title: Cancer Sci Volume: 108 Issue: 3 Pages: 435-443
  • DOI: 10.1111/cas.13163
  • NAID: 120006844097
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor?binding protein 2 in renal cell carcinoma (2017)
  • Author(s): Katayama Hiromichi、Tamai Keiichi、Shibuya Rie、Nakamura Mao、Mochizuki Mai、Yamaguchi Kazunori、Kawamura Sadafumi、Tochigi Tatsuo、Sato Ikuro、Okanishi Takamasa、Sakurai Kunie、Fujibuchi Wataru、Arai Yoichi、Satoh Kennichi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12016-12016
  • DOI: 10.1038/s41598-017-12191-z
  • NAID: 120006364089
  • Peer Reviewed / Open Access