| Project/Area Number |
16K07140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Fukushima Medical University (2019)
Tohoku University (2016-2018) |
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Principal Investigator |
SATO NAOKO 福島県立医科大学, 看護学部, 教授 (40457750)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 貴 東北大学, 医学系研究科, 教授 (10261629)
元井 冬彦 東北大学, 医学系研究科, 准教授 (30343057)
佐藤 冨美子 東北大学, 医学系研究科, 教授 (40297388)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / QOL / CRH / 癌 / ストレス |
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| Outline of Final Research Achievements |
The 5-year relative survival rate of pancreatic cancer in Japan is about 8.5% (2009-2011), which is the lowest among malignant neoplasm. Since the number of pancreatic cancer patients is increasing and the invasiveness associated with treatment is high, improving their quality of life (QOL) of patients is an issue.
Corticotoropin-releasing hormone (CRH) is secreted from the atrioventricular nucleus of the brain and plays a central role in stress response via the hypothalamus-pituitary-adrenal axis. CRH molecules are also present in major organ tissues other than the central nervous system, but their effects are unclear. This study aims to clarify clinically the significance of expression of CRH in tumor tissue by prospective study in patients with pancreatic cancer who intend to undergo surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の調査によって、術前から術後長期的な膵癌患者の臨床所見および患者自身が自覚する心身の症状をはじめとしたQOLや情動の経時的経過が明らかとなった。また、QOLにはどのような要因が影響しているのかなどが明らかとなり、患者のQOLを高める介入方法の検討に活用できる重要な知見を得た。本研究で蓄積したデータをもとに、今後さらにCRH系分子の発現状況との関連を組織学的に明らかにすることで、疾患の状況との関連を踏まえた心身に対する多角的なケアや治療的介入方法の開発に貢献できる可能性がある。
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