Epigenetic mechanism of adipocyte dysfunction under overnutrition
Project/Area Number |
16K07220
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
System genome science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Research Collaborator |
Kawamura Takeshi
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 脂肪細胞 / エピゲノム / 糖代謝 / ヒストンメチル化 / ヒストンアセチル化 / ヒストン脱メチル化 / ゲノム / 発現制御 / 糖 / 脂質 |
Outline of Final Research Achievements |
When the environment changes, cells change their character and adapt to the environmental changes. The character of cells are known to be regulated by epigenome, an acquired genetic information. Adipocytes uptake carbohydrate when energy is excess and store it as lipids. Adipocytes were cultured under conditions of excess or deficiency of carbohydrate, and gene expression and epigenome were comprehensively analyzed. It has been revealed that extracellular carbohydrate as well as histone methylation, one of the epigenome, regulate carbohydrate uptake and lipid accumulation in adipocytes.
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Academic Significance and Societal Importance of the Research Achievements |
代謝の良し悪しは遺伝的素因だけでなく、環境要因によって決まる。糖を取込み、脂肪を蓄えやすいといった性質は、糖そのものと後天的に書きかわるエピゲノムを介した仕組みで、脂肪細胞に記憶されていることが明らかになった。この知見は、体質改善やメタボリックシンドロームの予防に役立つと期待される。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.2018
Author(s)
Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
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Journal Title
Nature Communications
Volume: 9
Issue: 1
Pages: 1566-1566
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016
Author(s)
R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 28845-28845
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Cold stress-induced phosphorylated histone demethylase JMJD1A re-writes epigenetic memory for adaptive thermogenesis.2017
Author(s)
Yosuke Fujiwara, Yohei Abe, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
Organizer
The 72nd Fujihara Seminar
Related Report
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