| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
When the environment changes, cells change their character and adapt to the environmental changes. The character of cells are known to be regulated by epigenome, an acquired genetic information. Adipocytes uptake carbohydrate when energy is excess and store it as lipids. Adipocytes were cultured under conditions of excess or deficiency of carbohydrate, and gene expression and epigenome were comprehensively analyzed. It has been revealed that extracellular carbohydrate as well as histone methylation, one of the epigenome, regulate carbohydrate uptake and lipid accumulation in adipocytes.
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