| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In order to elucidate physiological function of ribosome-associated quality control (RQC), a quality control for aberrant protein synthesis, in neurons, we have performed a series of behavioral assays and neuron morphogenesis and survival analysis. we found that clearance of the proteins with CAT-tail which is a peptide tag attached to C-terminal end of nascent peptides during RQC and promote efficient degradation of nascent peptides is crucial for the maintenance of morphology of young developing neurons. CAT-tailed products are likely prone to aggregate and eventually induce cell death. On the other hands, knockdown of RQT (RQC trigger) factors in the mouse hippocampus affected anxiety and long-term memory formation.
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