| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Meiosis is a type of cell division , which generates haploid gametes. During meiosis in fission yeast, positions of telomeres and centromeres dramatically change and the change depends on the LINC nuclear membrane protein complexes. We found that telomeres regulate centromere positioning and that this regulation is crucial for proper spindle formation during meiotic divisions and nuclear fusion during cell conjugation. We developed a novel method for evaluation of meiosis-specific centromere structure, whose proper formation depends on centromere detachment from the LINC complexes. Furthermore, we found that telomere-mediated chiasma formation causes coordinated oscillatory movements of homologous chromosomes and that this oscillation probably contributes to proper spindle attachment of chromosomes.
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