| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
High levels of DNA damage or inhibition of DNA replication by some drugs interferes with DNA replication and hamper its progression, which causes “replication stress”. Replication stress triggers cell cycle arrest to prevent cell division with abnormal genome DNA due to uncompleted DNA replication. In this study, we found that inhibition of RB family, one of the important tumor suppressor gene products, leaded to reduction in cell response against replication stress, and even delayed recovery from the replication stress. Our experimental data suggested that RB family might play an important role in activation of proper molecular signaling in cells in response to the replication stress.
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