| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To clarify the detailed molecular mechanism of sulfation of a tyrosine residue, which is one of the post-translational modifications of proteins, the three-dimensional structure analysis of tyrosylprotein sulfotransferase (TPST) was done.
We have determined crystal structure of human tyrosyltransfease-1 using X-ray crystalography. This provided a lot of information on the molecular mechanism of the substrate recognition function of TPST.
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