| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Heat shock factor HSF1 is known as the major transcriptional regulator for chaperone genes, and it also regulates the expression of non-chaperone genes under normal growth conditions. In this study, I focused on the roles of HSF1-target genes, including immediate-early response factor IER5, general transcription factor TAF7, and cell growth regulator GADD45. IER5 functions as a modulator of protein phosphatase 2A and regulates the protein stability and activity of cell division cycle regulators. Heat-induced TAF7 is necessary for the prolonged expression of chaperone genes. GADD45 is necessary for heat stress survival. These results suggest that HSF1 is involved in the control of cell proliferation and death through regulating the expression of various non-chaperone target genes.
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