| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The endoplasmic reticulum (ER) stress response pathway is activated by accumulation of the aberrant protein within the ER and functions in the maintenance of cellular homeostasis. The AMPK orthologue Snf1 negatively regulates the Hog1 and Ire1 pathways in the budding yeast endoplasmic reticulum stress response. Here, we found that expression of the Snf1 regulatory subunit is induced by ER stress and that this induction is dependent on the Ire1 pathway. Our results revealed that the Snf1, the Hog1 pathway and the Ire1 pathway form a complex signal network.
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