| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The molecular mechanism of cytokinesis has been well studied using model organisms such as animal cells and yeast. For these cells, a "purse string model" has been proposed with a contractile ring composed of actomyosin. However, the myosin II that generates the driving force in this model exists only in the Opisthokont. In this study, we investigated cytokinesis of the ciliate Tetrahymena in order to gain a further understanding of the molecular and cellular biology of cytokinesis in other groups. As a result, we found that the formin family proteins are localized in the basal body BB and may be involved in determining the position of the cleavage furrow by controlling the intracellular geometry. We also found that a protein kinase that distributes in the early BB and then translocates to the longitudinal microtubule is required for progression of cytokinesis.
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