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Investigation of cell chirality formation mechanisms in Drosophila primary cultured macrophage

Research Project

Project/Area Number 16K07349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

Sasamura Takeshi  大阪大学, 理学研究科, 講師 (70647487)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords細胞キラリティ / アクチン細胞骨格 / 左右非対称性 / ショウジョウバエ / マクロファージ / II型ミオシン / 血球細胞 / フィロポディア / アクチン / 貪食細胞 / 細胞骨格 / 発生・分化 / 細胞生物 / 左右非対称形成
Outline of Final Research Achievements

Recently, it has been revealed that individual cells have a property which shows left-right asymmetry, and this property is called cell chirality. It is suggested that cell chirality is important for formation of left-right asymmetry of internal organs, but the mechanisms generating cell chirality is not understood well. We revealed that the mechanism of cell chirality generation at molecular levels. It is well established that actin filament is important for cell shape change, and we found the movement of actin filament is important for generation of cell chirality for the first time.

Academic Significance and Societal Importance of the Research Achievements

我々人の内臓はほとんどが左右非対称な形をしており、内臓が機能するためにその形が必要があることが多い。そのため、再生医療などの最先端の治療には、形態がどのようにしてつくられるかを知ることが必要不可欠であるが、その機構は不明な点が多く残されている。今回の結果は細胞の左右性をつくる仕組みを明らかにしており、それを制御することで、内臓の左右非対称な形態をつくりだす方法に繋がる可能性を秘めている。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Cell Chirality Drives Left-Right Asymmetric Morphogenesis2018

    • Author(s)
      Inaki Mikiko、Sasamura Takeshi、Matsuno Kenji
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 6 Pages: 1-9

    • DOI

      10.3389/fcell.2018.00034

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Actin cytoskeleton generates cell chirality in Drosophila macrophages2020

    • Author(s)
      笹村剛司
    • Organizer
      日本分子生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ショウジョウバエ血球細胞のキラリティはアクチン細胞骨格によって形成 される2019

    • Author(s)
      笹村 剛司、栗栖 大祐、 須志田 隆道、秋山 正和、 大友 康平、根本 知己、 水野 裕昭、渡邊 直樹、 三好 洋美、金子 新、 松野 健治
    • Organizer
      日本細胞生物学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Chirality in the dynamic behavior of blood cell cytoplasm in Drosophila2019

    • Author(s)
      Takeshi Sasamura, Daisuke Kurisu, Masakazu Akiyama, Kohei Otomo, Tomomi Nemoto, Hiroaki Mizuno, Naoki Watanabe, Hiromi Miyoshi, Arata Kaneko, Kenji Matsuno
    • Organizer
      日本発生生物学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Chirality in the dynamic behavior of blood cell cytoplasm in Drosophila2018

    • Author(s)
      Takeshi Sasamura, Daisuke Kurisu, Masakazu Akiyama, Kohei Otomo, Tomomi Nemoto, Hiroaki Mizuno, Naoki Watanabe, Kenji Matsuno
    • Organizer
      日本細胞生物学会・日本発生生物学会合同大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 笹村剛司・栗栖大祐・秋山 正和・大友 康平・根本 知己・水野 裕昭・渡邊 直樹・松野健治2018

    • Author(s)
      ショウジョウバエ血球細胞が示す細胞質動態のキラリティ
    • Organizer
      日本生化学会
    • Related Report
      2018 Research-status Report
  • [Presentation] ショウジョウバエ血球細胞が示す細胞質動態のキラリティ2017

    • Author(s)
      笹村剛司・栗栖大祐・秋山 正和・松野健治
    • Organizer
      日本動物学会 第88回 富山大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Chirality in the dynamic behavior of blood cell cytoplasm in Drosophila2017

    • Author(s)
      笹村剛司・栗栖大祐・秋山正和・大友康平・根本知己・水野裕昭・渡邊直樹・松野健治
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-01-27  

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