| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The Golgi stress response is a homeostatic mechanism that augments capacity of the Golgi function in accordance with cellular demands. We initiated the research of the Golgi stress response and identified the TFE3 pathway of the Golgi stress response, which upregulates the general function of the Golgi. In this research project, we discovered a novel response pathway of the Golgi stress response, the proteoglycan pathway. We identified target genes such as HS6ST1 and NDST2, an enhancer element PGSE and transcription factors that belong to the KLF family. We will identify the sensor molecule that detects Golgi stress and activates the transcription factors in order to clarify the molecular mechanism of the mammalian Golgi stress response in near future.
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