Studies on the signal transduction network connecting the ubiquitin-proteasome system to the extracellular nutritional environment
| Project/Area Number |
16K07359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Konan University |
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Principal Investigator |
Takeda Kojiro 甲南大学, 理工学部, 准教授 (90426578)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 栄養素 / タンパク質分解 / ホスファターゼ / Greatwallキナーゼ / 分裂酵母 / プロテアソーム / Endosulfine / PP2A / 細胞周期 / 栄養 / シグナル伝達 |
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| Outline of Final Research Achievements |
The aim of this research is to elucidate the signal transduction network that connects extracellular nutritional environment to regulations of intracellular proteolysis system, especially, the ubiquitin proteasome system, by using the fission yeast S. pombe as a model. Because we had preliminary results suggesting the evolutionally conserved Greatwall kinase (Gwl)/alpha-Endosulfine (Ensa)-PP2A pathway may be involved, we focused on this pathway. We clarified proteins composing Gwl/Ensa-PP2A pathway in the fission yeast and the physiological functions of the pathway. We also obtained results strongly suggesting that the fission yeast Gwl/Ensa-PP2A pathway is engaged in transmitting extracellular nutritional information to the proteasome or the localization factor(s) of the proteasome.
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| Academic Significance and Societal Importance of the Research Achievements |
プロテアソームに依存したタンパク質分解は，細胞周期やシグナル伝達などの真核生物に普遍的な生命現象に関与しているにとどまらず，老化や寿命への関連も指摘され注目されている。また，栄養状態や代謝が老化や寿命に大きな影響を持つことも広く受け入れられている。本研究は，栄養とプロテアソーム周辺を結びつける細胞内のシグナル伝達ネットワークに焦点をあわせている。また，実験材料は菌類である酵母であるものの，注目している分子群はいずれもヒトまで保存されたものであり，基礎医学分野への将来的な情報の提供という意味合いで学術的・社会的意義がある。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Nutrient signaling via the TORC1-greatwall-PP2AB55δ pathway is responsible for the high initial rates of alcoholic fermentation in sake yeast strains of Saccharomyces cerevisiae.2018
Author(s)
D. Watanabe, T. Kajihara, Y. Sugimoto, K. Takagi, M. Mizuno, Y. Zhou, J. Chen, K. Takeda, H. Tatebe, K. Shiozaki, N. Nakazawa, S. Izawa, T. Akao, H. Shimoi, T. Maeda, and H. Takagi
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Journal Title
Appl. Environ. Microbiol.
Volume: 85
Issue: 1
DOI
Related Report
Peer Reviewed
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