| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The function of the novel gene shiome, which controls planar cell polarity (PCP) formed on the epithelial tissues, was investigated using Drosophila. As a result, it was revealed that the PCP of the adult wing was disrupted by overexpression of shiome, larvae of shiome mutants showed the disruption of PCP on the epidermal cuticle, and shiome was required for molting from the first instar to the second instar larvae. Furthermore, biochemical studies showed that Shiome was secreted protein. Based on the above results, we concluded that Shiome is a multifunctional secretory protein required for establishment of PCP and molting in Drosophila.
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