• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on RNA regulation and reprogramming by maternal effect factors

Research Project

Project/Area Number 16K07383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research Institution医療法人徳洲会野崎徳洲会病院(附属研究所) (2018)
Institute of Physical and Chemical Research (2016-2017)

Principal Investigator

Toshie Shinagawa  医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 部長 (70344041)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords母性効果因子 / Zar1 / Zar2 / RNA結合因子 / 減数分裂 / 接合子ゲノム活性化 / 卵子 / 標的RNA
Outline of Final Research Achievements

Zygotic genomes are transcriptionally silent for a while after fertilization. Pre-implantation embryo development is dependent on RNAs and proteins stored in oocyte but it is yet unknown how they are regulated. In this study, we found that zygote arrest 1 (Zar1), a maternal effect factor required for zygotic genome activation, is enriched on 3’ UTR of mRNAs that are involved in oocyte meiosis. The results suggest that regulation of meiosis-related genes is important for development of early embryos.

Academic Significance and Societal Importance of the Research Achievements

老化した卵子では減数分裂の異常がしばしば観察される。卵子中のZar1の発現量は年齢が高くなるにつれ減少することが知られており、Zar1の減少と減数分裂の異常、卵子の老化は密接に関わっていると考えられる。本研究の結果は、卵子の老化メカニズム解明に大きなヒントを与えるものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b.2017

    • Author(s)
      Padavattan S et al.
    • Journal Title

      Biophys. Chem.

      Volume: 221 Pages: 41-48

    • DOI

      10.1016/j.bpc.2016.11.013

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 高齢マウスにおける精原幹細胞維持にヒストンバリアントTH2AとTH2Bが貢献している2017

    • Author(s)
      品川 敏恵、My Linh HUYNH、石井 俊輔
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi