• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the mechanism of gene expression that contributes to stem cell differentiation and homeostasis

Research Project

Project/Area Number 16K07396
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plant molecular biology/Plant physiology
Research InstitutionKyoto University

Principal Investigator

Tsugeki Ryuji  京都大学, 理学研究科, 助教 (50303805)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords植物幹細胞
Outline of Final Research Achievements

In plants, the meristems harboring stem cells are central to post-embryonic formation of organs and tissues. To understand plant growth and development, it is important to reveal the mechanisms that contribute to stem cell differentiation and homeostasis. Arabidopsis thaliana VAH was identified as a gene that influences stem cell differentiation and homeostasis. Present data suggest that VAH mediates negative control of stemness in the shoot and root. It appears that VAH protein forms a multi-protein complex in vivo.
A plant hormone auxin is important for stem cell differentiation and homeostasis. It has been shown that local auxin biosynthesis is important for development of vascular stem cells in leaves.

Academic Significance and Societal Importance of the Research Achievements

幹細胞の重要な性質の1つは、細胞増殖する能力を持つことである。一方、幹細胞から器官が作られる際には、その増殖能を適切に失う必要もある。例えば、増殖能を持ち続けてしまうと、不必要な細胞増殖が起きて、不具合を生じてしまうだろう。しかしながら、どのように幹細胞らしさが喪失されるのかほとんどわかっていない。幹細胞らしさの維持についての研究は多いが、消失に着目した研究はほとんどない。VAHは幹細胞らしさの消失に関わる新規な遺伝子であり、似た遺伝子がヒトにも存在する。VAHの研究は、植物幹細胞の理解だけでなく、動物幹細胞の理解にも繋がると期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (4 results)

  • [Int'l Joint Research] フライブルグ大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] フライブルグ大学(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] フライブルグ大学(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] フライブルグ大学(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Presentation] 幹細胞らしさに関わるタンパク質の分子生化学的同定の試み2020

    • Author(s)
      槻木竜二, 森 仁志
    • Organizer
      第61回 日本植物生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 幹細胞らしさを負に制御する遺伝子の解析2019

    • Author(s)
      槻木竜二
    • Organizer
      第60回 日本植物生理学会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] Genetic Analysis of Genes Influencing Stem-Cell Homeostasis in Arabidopsis2019

    • Author(s)
      Ryuji Tsugeki
    • Organizer
      Japan-Taiwan Plant Biology 2019
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 幹細胞らしさの喪失に関わる遺伝子の解析2018

    • Author(s)
      槻木竜二
    • Organizer
      第59回 日本植物生理学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 幹細胞らしさを負に制御するVAH遺伝子の解析2017

    • Author(s)
      槻木竜二
    • Organizer
      第58回 日本植物生理学会年会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 幹細胞らしさの喪失を促す遺伝子の解析2016

    • Author(s)
      槻木竜二、寺田志穂
    • Organizer
      日本植物学会第80回沖縄大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 京都大学理学研究科植物学教室・年報(2019 年度)

    • URL

      http://www.bot.kyoto-u.ac.jp/annual/5_iden.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 京都大学理学研究科植物学教室・年報(2018 年度)

    • URL

      http://www.bot.kyoto-u.ac.jp/annual/5_iden.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 京都大学理学研究科植物学教室・年報(2017 年度)

    • URL

      http://www.bot.kyoto-u.ac.jp/annual/5_iden.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 京都大学理学研究科植物学教室・年報(2016 年度)

    • URL

      http://www.bot.kyoto-u.ac.jp/annual/5_iden.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi