| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We analyzed biological function of NIMA-related kinases (NEK) to address microtubule-dependent growth polarity in plants. Arabidopsis NEK6 localizes to shrinking ends of microtubules and phosphorylates five amino acid residues of beta-tubulin, which induces depolymerization of aberrant microtubules (Takatani et al. 2017 Sci. Rep.). Recently, we found novel function of NEK6 in organ growth. NEK6 curbs microtubule response to tensile stress during organ development to buffer growth variation and to suppress organ deformation (Takatani et al. 2020 Curr. Biol.). Using a basal land plant Marchantia polymorpha, we revealed that NEK-microtubule regulatory module is evolutionary conserved. Marchantia MpNEK1 localizes to the apical dome of rhizoids to stabilize the direction of tip growth of rhizoids (Otani et al. 2018 Development).
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