Elucidation of biological roles of novel neuropeptides, Ci-YFV/L, identified in the ascidian, Ciona intestinalis
| Project/Area Number |
16K07430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Suntory Foundation for Life Sciences |
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Principal Investigator |
Satake Honoo 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 主幹研究員 (20280688)
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| Research Collaborator |
Shiraishi Akira
Osugi Tomohiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | カタユウレイボヤ / 神経ペプチド / 受容体 / ペプチド / 卵巣 / 生理活性 / 内分泌 / 卵胞成長 / 進化 |
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| Outline of Final Research Achievements |
Ci-YFV-1, 2, 3, and Ci-YFL are novel Ciona-specific neuropeptides. Their cognate receptors and biological roles remained to be elucidated. In this study, we develop an original machine learning system to predict specific interaction between neuropeptides and receptors, and evauluated the predicted results. The cell-based funtional assays led to the elucidation of specific receptors for Ci-YFV-1 reeptor and Ci-YFV-3 receptors were found to be expressed in the central nervous system and atrial siphon. Furthermore, the former was also expressed specifically in the endostyle, whreas specific expression of the latter was detected in the oral siphon.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、これまで全く不明だったホヤ特異的な神経ペプチドやペプチドホルモンの生物学的な役割を解明することや、神経系や内分泌系がどのように進化・多様化してきたかをという、生物の本質的な問いに答える研究に展開できることが期待できます。さらに、本研究で開発した機械学習システムを活用することで、ヒトをはじめとする生物に存在する神経ペプチドやペプチドホルモンの受容体を高い確率で、そして、短時間で予測することが可能となり、これまで知られていなかったペプチド‐受容体の相互作用の法則を解明し、その成果を創薬に応用できます。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Calcitonin-typical suppression of osteoclastic activity by amphioxus calcitonin superfamily peptides and insights into the evolutionary conservation and diversity of their structures.2017
Author(s)
Sekiguchi, T., Shiraishi, A., Satake, H., Kuwasako, K., Takahashi, H., Sato, M., Urata, M., Wada, S., Endo, M., Ikari, T., Hattori, A., Srivastav, A.K. and Suzuki, N.
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Journal Title
Gen. Comp. Endocrinol.
Volume: 246
Pages: 294-300
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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