Analysis of olfactory receptors in odorant-induced physiological reponses

• Project/Area Number: 16K07445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Kansai Medical University
• Principal Investigator: MATSUO Tomohiko 関西医科大学, 医学部, 研究員 (90641754)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経科学 / 嗅覚受容体 / 匂い / 恐怖情動

Outline of Final Research Achievements

Specific odorants induce innate, genetically-determined, behaviors and/or physiological responses without prior learning. Receptors and neural mechanisms underlying these odorant-induced innate responses have been poorly understood. Functional analysis of receptors, which were identified in our in vitro and in vivo screenings, demonstrated several candidate receptors and brain regions responsible for odorant-induced innate behaviors.

Academic Significance and Societal Importance of the Research Achievements

これまで、後天的な学習によらず、先天的な機構で特定の行動・生理応答を誘発する匂い物質と結合する受容体、またその匂い情報を受容し行動・生理応答の発現に関与する脳領域について知られていることは少なかった。本研究により、一連の生体応答の起点となる匂い物質の受容体、およびその下流で機能する脳領域の同定に繋がる結果を得ることができた。これらにより、匂い物質を用いて人体に有益あるいは有害動物などに不利益に働くような生理応答を人為的に誘発できるような系の開発につながる可能性が考えられる。

Research Products

• [Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018)
  • Author(s): Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2041-2041
  • DOI: 10.1038/s41467-018-04324-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway (2018)
  • Author(s): Otsubo Yoko、Matsuo Tomohiko、Nishimura Akiko、Yamamoto Masayuki、Yamashita Akira
  • Journal Title: EMBO Reports Volume: 19 Issue: 3
  • DOI: 10.15252/embr.201744867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Main olfactory system-mediated social behaviors in mice (2016)
  • Author(s): Tomohiko Matsuo, Tatsuya Hattori, Akari Asaba, Naokazu Inoue, Nobuhiro Kanomata, Takefumi Kikusui, Reiko Kobayakawa, and Ko Kobayakawa
  • Organizer: 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2016-06-05
  • Int'l Joint Research