| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
For understanding the development of animals, it is important to reveal the landscape of epigenetic changes in cells during differentiation process. However, analyzing whole differentiation processes in various cell types is laborious and impossible for some organisms. In this study, phylogenetic analysis is applied to reconstruct developmental processes based on the developmental changes of epigenomes of differentiated cells. Using epigenomes of eight types of differentiated human hematopoietic cells, ancestral state estimation based on a phylogenetic tree was applied to map the epigenomic changes of six kinds of histone modifications onto the hierarchical cell differentiation process of hematopoiesis. As a result, it was shown that this approach could infer an appropriate landscape of histone modification changes during hematopoiesis.
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