| Project/Area Number |
16K07540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | Yamagata University |
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Principal Investigator |
Niizeki Kyuichi 山形大学, 大学院理工学研究科, 教授 (00228123)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 起立 / 心拍出量 / 血管抵抗 / 位相同期 / 脳血流速度 / 呼吸位相 / カフ圧負荷 / 受動的筋ポンプ / 自律神経活動 / 起立負荷 / ヒールアップ動作 / 一回拍出量 / 周波数解析 / 全身的協関 / 脳血流 / 位相反応 |
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| Outline of Final Research Achievements |
The purpose of the present study was to determine whether phase coupling occurs between heartbeats and rhythmic lower-leg cuff inflation (RCI) which mimics muscle pump function, and to investigate the effect of the timing of muscle pump with respect to respiration on orthostatic cardiovascular autonomic responses. A periodic phase coupling occurred between heartbeats and RCI during quiet standing (QS). The RCI led to increase in stroke volume (SV) and lengthening of R-R intervals (RRI), however, these were not related with the strength of phase coupling. Reduction in SV and an increase in total peripheral resistance observed in QS were suppressed by repetitive heel up (HUP) maneuver. When HUP was initiated at expiration, blood pressure (BP) was increased and when initiated at inspiration, respiratory modulation in RRI was increased. These results indicate that orthostatic cardiovascular and autonomic responses are influenced by the timing of muscle pump with respect to respiration.
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| Academic Significance and Societal Importance of the Research Achievements |
筋ポンプ作用は静脈還流量を増し，起立時の心拍出量維持に寄与している。しかし，その機能が呼吸ポンプ作用によってどのように修飾されるのか生理学的実証はなされていない。本研究は，起立時に筋ポンプ動作(踵上げ運動)を吸気開始に行う場合と呼気開始に行う場合で循環系指標の挙動を解析した。呼気時の筋ポンプ動作は血圧を上昇させ，心拍と血圧の呼吸性変動を減弱させるが，吸気時の筋ポンプ動作は逆に呼吸性変動を増大させ，心拍間隔を延長させた。吸気のタイミングで行う筋ポンプ動作は迷走神経活動を亢進させることが示唆され，起立不耐性を示す患者に有効な対処療法となり得ると考えられた。
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