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The effect of insulin in the central nervous system on fat oxidation during exercise

Research Project

Project/Area Number 16K07544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied anthropology
Research InstitutionOsaka City University

Principal Investigator

Yokoyama Hisayo  大阪市立大学, 都市健康・スポーツ研究センター, 准教授 (10647829)

Co-Investigator(Kenkyū-buntansha) 岡崎 和伸  大阪市立大学, 都市健康・スポーツ研究センター, 教授 (70447754)
今井 大喜  大阪市立大学, 都市健康・スポーツ研究センター, 講師 (40614483)
Project Period (FY) 2016-10-21 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords鼻腔内インスリン投与 / 中枢神経系 / 脂肪酸化 / 漸増運動負荷 / 過体重 / 脂肪分解 / 中枢インスリン作用 / 臓器間ネットワーク / 運動時エネルギー代謝 / 脂肪酸化率 / 生活習慣病 / インスリン作用 / エネルギー代謝 / 体力医学
Outline of Final Research Achievements

The effects of the intranasal administration (AD) of insulin (INS) on the maximum fat oxidation rate (maxFOR) during exercise were tested in 15 young normal-weight (N group) and 8 young overweight (O group) persons. On two separate days, either INS or placebo (PL) was randomly administered intranasally before a graded exercise test. Indirect calorimetry was used to assess maxFOR and FATmax during exercise. Blood INS and glucose levels did not change after INS AD. In the N group, maxFOR was reduced by INS AD. MaxFOR was significantly smaller in the O group than in the N group and was not influenced by INS AD. Exercise-induced elevation in blood epinephrine levels tended to be reduced by INS AD only in the N group.
Intranasal INS AD reduces fat oxidation during exercise without any peripheral effects, possibly by suppressing sympathetic nerve activity. This inhibitory effect is diminished in the O-group, suggesting that cerebral insulin effects are attenuated in this population.

Academic Significance and Societal Importance of the Research Achievements

本研究は鼻腔内インスリン投与が血中インスリン濃度を上昇させることなく、運動時の脂肪酸化を抑制することを初めて明らかにした。一方、鼻腔内インスリン投与による運動中の脂肪酸化抑制効果が過体重で消失したことから、過体重では脳内インスリン作用が減弱しているものと考えられた。肥満の改善により脳のインスリン感受性が可逆的に向上するかどうかは臨床上重要な課題であり、今後の検討が必要である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Inhibitory Effects of Intranasal Administration of Insulin on Fat Oxidation during Exercise Are Diminished in Young Overweight Individuals2018

    • Author(s)
      Yokoyama Hisayo、Takeda Ryosuke、Kawai Eriko、Ota Akemi、Morita Emiko、Imai Daiki、Suzuki Yuta、Morioka Tomoaki、Emoto Masanori、Inaba Masaaki、Okazaki Kazunobu
    • Journal Title

      Journal of Clinical Medicine

      Volume: 7 Issue: 10 Pages: 308-308

    • DOI

      10.3390/jcm7100308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolism2017

    • Author(s)
      Yokoyama H, Takeda R, Kawai E, Hanno G, Ota A, Morita E, Imai D, Morioka T, Emoto M, Inaba M, Okazaki K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 6 Issue: 6 Pages: 459-468

    • DOI

      10.7600/jpfsm.6.459

    • NAID

      130006224795

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Presentation] Inhibitory effects of intranasal insulin administration on fat oxidation during exercise are diminished in overweight young individuals2018

    • Author(s)
      Hisayo Yokoyama, Ryosuke Takeda, Eriko Kawai, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Tomoaki Morioka, Masanori Emoto, Masaaki Inaba, Kazunobu Okazaki
    • Organizer
      American Diabetes Association the 78th Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鼻腔内インスリン投与による運動中の脂肪酸化抑制効果は過体重で消失する2018

    • Author(s)
      横山久代、竹田良祐、河合英理子、半野源太、太田暁美、森田恵美子、今井大喜、鈴木雄太、森岡与明、絵本正憲、稲葉雅章、岡崎和伸
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Presentation] Effects of intranasal insulin administration on fat oxidation during exercise in normal-weight and overweight young individuals2018

    • Author(s)
      Hisayo Yokoyama, Ryosuke Takeda, Eriko Kawai, Genta Hanno, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Tomoaki Morioka, Masanori Emoto, Masaaki Inaba, Kazunobu Okazaki
    • Organizer
      The 95th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibitory effects of intranasal insulin administration on fat oxidation during exercise are diminished in overweight young individuals2018

    • Author(s)
      Hisayo Yokoyama, Ryosuke Takeda, Eriko Kawai, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Tomoaki Morioka, Masanori Emoto, Masaaki Inaba, Kazunobu Okazaki
    • Organizer
      American Diabetes Association 78th Scientific Sessions
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Delivery of insulin to the brain by intranasal administration reduces fat oxidation during exercise in healthy young persons2017

    • Author(s)
      Nooshin Naghavi、横山久代、竹田良祐、太田暁美、森田恵美子、河合英理子、半野源太、今井大喜、岡崎和伸
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市中区)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 鼻腔内インスリン投与による脳内高インスリン状態は運動時の脂肪酸化を抑制する2017

    • Author(s)
      横山久代、Nooshin Naghavi、竹田良祐、太田暁美、森田恵美子、河合英理子、半野源太、今井大喜、森岡与明、絵本正憲、稲葉雅章、岡崎和伸
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] 脳内高インスリン状態が運動時の脂肪酸化に及ぼす影響2017

    • Author(s)
      横山久代、竹田良祐、河合英理子、半野源太、太田暁美、森田恵美子、今井大喜、森岡与明、絵本正憲、稲葉雅章、岡崎和伸
    • Organizer
      第5回日本糖尿病療養指導学術大会 若手研究者助成報告
    • Related Report
      2017 Research-status Report
  • [Presentation] 鼻腔内インスリン投与による脳内高インスリン状態は運動時の脂肪酸化を抑制する2017

    • Author(s)
      横山久代、竹田良祐、河合英理子、半野源太、太田暁美、森田恵美子、今井大喜、森岡与明、絵本正憲、稲葉雅章、岡崎和伸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 鼻腔内インスリン投与による脳内高インスリン状態は運動時の脂肪酸化を抑制する2017

    • Author(s)
      横山久代、竹田良祐、河合英理子、半野源太、太田暁美、森田恵美子、今井大喜、森岡与明、絵本正憲、稲葉雅章、岡崎和伸
    • Organizer
      第54回日本糖尿病学会近畿地方会
    • Related Report
      2017 Research-status Report

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Published: 2016-10-24   Modified: 2020-03-30  

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