| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Magnetotactic bacterium orients and swims along the geomagnetic field using magnetic organelle, termed magnetosome, which is positioned in a chain-like configuration in the cells. In this study, we revealed the physiological role of MamK cytoskeleton by using live-cell imaging techniques. The results showed that the MamK cytoskeleton tethers magnetosomes in a static chain to prevent diffusion or aggregation of magnetosomes by a physical disturbance such as simple diffusion. Furthermore, we characterized polymerization properties of the MamK cytoskeleton and showed that MamK filament has polarity similar to eukaryotic actin.
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