| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Nutritional restrictions are known to increase the lifespan of various organisms. In this study, we found that sulfur restriction extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The sulfur restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These cellular responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also found that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl11 gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS in fission yeast. Therefore, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.
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