| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
PF1171F is a cyclic hexapeptide with paralytic activity against silkworm larvae via oral administration. To elucidate its conformation in pseudo body’s internal environment (aqueous solution and silkworm’s hemolymph), PF1171F whose nitrogen atoms were labeled with 15N was analyzed by 1H-15N 2-dimentional Nuclear Magnetic Resonance (NMR) experiments. The conformation in aqueous solution was found to be quite different from those in organic solvents. On the other hand, no NMR signals were observed in the 2D spectrum of PF1171F in silkworm’s hemolymph. This might be because PF1171F sticks to large biomolecules such as hemocytes.
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