Analysis and applications of the protective role of ether phospholipids on arteriosclerosis
| Project/Area Number |
16K07728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Research Collaborator |
YAMAZAKI YUYA 株式会社ADEKA
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エーテル型リン脂質 / 動脈硬化 / 閉経 / プラスマローゲン / 卵巣摘出 |
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| Outline of Final Research Achievements |
In this study, we investigated the involvement of ether-type phospholipids including plasmalogen on arteriosclerosis using cultured cells and animals, and it has been shown that plasmalogen is involved in the cholesterol efflux in peripheral tissues. Also, our findings indicate that plasmalogen is decreased in the blood with aging and ovariectomy, suggesting that plasmalogen may be involved in postmenopausal arteriosclerosis. These findings indicate the novel function of ether phospholipids and could contribute to the human health.
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| Academic Significance and Societal Importance of the Research Achievements |
動脈硬化症、さらに閉経後の動脈硬化症にもエーテル型リン脂質の関与を示唆する結果を得た。この結果は、エーテル型リン脂質の新たな生理機能を提案するとともに、ヒトの健康に大きく寄与しうるものである。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Serum ethanolamine plasmalogens improve detection of cognitive impairment among elderly with high excretion levels of urinary myo-inositol: A cross-sectional study.2016
Author(s)
Maeba R, Araki A, Ishii K, Ogawa K, Tamura Y, Yasunaga M, Minami U, Komori A, Okazaki T, Nishimukai M, Hara H, Fujiwara Y.
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Journal Title
Clin Chim Acta.
Volume: 453
Pages: 134-140
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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