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Transport-fate of amphiphiles by using biophysical approaches

Research Project

Project/Area Number 16K07739
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionKyushu University

Principal Investigator

SHIROUCHI BUNGO  九州大学, 農学研究院, 助教 (00548018)

Research Collaborator SATO Masao  
TAKEYAMA Ai  
TERAMOTO Asami  
ARIMA Yuko  
KAJIHARA Chisato  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords両親媒性物質 / グリセロリン脂質 / 門脈 / リンパ / 門脈系輸送 / リンパ系輸送
Outline of Final Research Achievements

Using thoracic lymph duct- and portal vein-cannulated rats, we investigated the absorption and transport dynamics of dietary amphiphiles (glycerophospholipids; glyceroPL) and the effects of dietary glyceroPL on lymphatic transports of other dietary lipids. We found that dietary PS reduced gastric emptying through stimulation of gut hormone secretion. In addition, we observed that dietary sn-1 lysoPL decreased lymphatic TAG levels, whereas dietary sn-2 lysoPL decreased lymphatic cholesterol levels. These results suggest that different actions of sn-1 and sn-2 lysoPLs exert through the physicochemical properties in the gut. Limited information was available regarding intakes of PL molecular classes among Japanese people from diets and food sources. We quantified the contents of them in 120 meals and conducted a stepwise multiple regression analysis to identify predictors of each PL class intake. Our results determined the daily intake of each PL class and the food sources of PC and PE.

Academic Significance and Societal Importance of the Research Achievements

これまでに、主要なリン脂質クラスの栄養生理機能に関する知見が積み上げられてきており、微量リン脂質クラスについてはその摂取量の少なさから、栄養生理機能に関する情報も少ない。本研究において、微量リン脂質クラス(PS, LysoPL)の栄養生理機能を見出し、その作用機序が腸管を起点していることを明らかとした。また、実際の食事中に含まれるリン脂質クラスごとの摂取量を示すとともに、推定統計学的手法が機能性成分の供給源予測に活用できることを新たに提示した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Quantities of Phospholipid Molecular Classes in Japanese Meals and Prediction of Their Sources by Multiple Regression Analysis2018

    • Author(s)
      SHIROUCHI Bungo、YAMANAKA Rikako、TANAKA Shoji、KAWATOU Fagyun、HAYASHI Takuya、TAKEYAMA Ai、NAKAO Akiko、GOROMARU Ryoko、IWAMOTO Masako、SATO Masao
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 64 Issue: 3 Pages: 215-221

    • DOI

      10.3177/jnsv.64.215

    • NAID

      130007413181

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantities of phospholipid molecular classes in Japanese meals and prediction of their sources by multiple regression analysis2018

    • Author(s)
      Shirouchi B, Yamanaka R, Tanaka S, Kawatou F, Hayashi T, Takeyama A, Nakao A, Goromaru R, Iwamoto M, Sato M
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 印刷中

    • NAID

      130007413181

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 食事リン脂質の脂質代謝調節に関する研究2019

    • Author(s)
      城内文吾
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リゾリン脂質は腸管での物理化学的特性を介してリンパ脂質輸送を低下させる2019

    • Author(s)
      武山藍、城内文吾、寺本麻未、Wang Tianyu、佐藤匡央
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Alleviation of metabolic syndrome with dietary egg white protein2018

    • Author(s)
      Bungo Shirouchi
    • Organizer
      日本油化学会第57回年会 JOCS-AOCS Joint Symposium (Health and Nutrition)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リゾリン脂質摂取がリンパ液中脂質濃度に及ぼす影響2018

    • Author(s)
      武山 藍、城内文吾、寺本麻未、Wang Tianyu、佐藤匡央
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホスファチジルセリン摂取は消化管ホルモン分泌を介して胃排出を抑制する2018

    • Author(s)
      城内文吾、寺本麻未、武山 藍、佐藤匡央
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホスファチジルコリン摂取後のリンパ液中サイトカイン濃度2018

    • Author(s)
      武山藍、城内文吾、河内明日香、有馬優子、佐藤匡央
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 日本人の食事中リン脂質クラスの定量およびそれらの食物源の重回帰分析予測2017

    • Author(s)
      城内文吾、山中理華子、田中翔士、河東華均、林拓也、中尾晶子、五郎丸瞭子、岩本昌子、佐藤匡央
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ホスファチジルセリン摂取による胃排出遅延作用2017

    • Author(s)
      寺本麻未、城内文吾、武山藍、佐藤匡央
    • Organizer
      平成29年度 日本食品科学工学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of dietary phosphatidylserine on gastric emptying and postprandial glycemic response in rats2017

    • Author(s)
      Teramoto A, Shirouchi B, Sato M
    • Organizer
      AFELiSA (International Symposium on Agriculture, Food, Environmental and Life Science in Asia) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 胆管結紮によるリンパ脂質吸収の抑制および回腸の炎症に対する大豆由来ホスファチジルコリンの効果2016

    • Author(s)
      梶原千聖,城内文吾,有馬優子,佐藤匡央
    • Organizer
      平成28年度日本栄養・食糧学会九州・沖縄支部大会
    • Place of Presentation
      大分大学教育学部(大分県大分市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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