| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The metabolic syndrome is known to increase cardiovascular morbidity and mortality.Because precise mechanism of lowered HDL-cholesterol in metabolic syndrome is still unknown, we examined the effects of several food factors on HDL metabolism in metabolic syndrome models. Our study demonstrated that number and position of trans-structure in fatty acids affect apoB secretion in vitro, but not LDL-C level in vivo. On the other hand, our results suggested that plant protein alleviate LDL-C/HDL-C ratio through an increase of hepatic sterol transporter expression in obese rats. Therefore, regulation of hepatic sterol transporter is worth considerable attention with respect to the alleviation of lowered HDL metabolism in metabolic syndrome by food components.
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