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HDL metabolism and food in metabolic syndrome

Research Project

Project/Area Number 16K07740
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionSaga University

Principal Investigator

Koji Nagao  佐賀大学, 農学部, 教授 (10336109)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords食環境 / HDL代謝 / 疾患遺伝子 / メタボリックシンドローム / コレステロール逆転送系 / コレステロール代謝 / リポタンパク質代謝
Outline of Final Research Achievements

The metabolic syndrome is known to increase cardiovascular morbidity and mortality.Because precise mechanism of lowered HDL-cholesterol in metabolic syndrome is still unknown, we examined the effects of several food factors on HDL metabolism in metabolic syndrome models. Our study demonstrated that number and position of trans-structure in fatty acids affect apoB secretion in vitro, but not LDL-C level in vivo. On the other hand, our results suggested that plant protein alleviate LDL-C/HDL-C ratio through an increase of hepatic sterol transporter expression in obese rats. Therefore, regulation of hepatic sterol transporter is worth considerable attention with respect to the alleviation of lowered HDL metabolism in metabolic syndrome by food components.

Academic Significance and Societal Importance of the Research Achievements

欧米における疫学調査から、HDL代謝を低下させる動脈硬化性疾患の危険因子として幾つかの脂質成分が挙げられているが、作用機序と構造との関係に関する詳細は不明である。本研究では、俗に言うトランス型脂肪酸がHDL代謝に及ぼす影響を細胞系および生体系で検討を行ったが、その悪玉性は証明されなかった。一方で、植物性タンパク質が肝臓のステロールトランスポーターの発現を変動させることで生体でのHDLコレステロールの比率を向上させることを見出した。以上のことから、今後の病態発症機序解明と代謝改善機能性食事因子の開発におけるターゲットとなる疾患遺伝子を強く示唆することが出来た。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (27 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Evaluating the Content and Distribution of <i>Trans</i> Fatty Acid Isomers in Foods Consumed in Japan2019

    • Author(s)
      N. Gotoh, K. Yoshinaga, S. Kagino, Y. Katoh, Y. MIzuno, F. Beppu, T. Nagai, H. Mizobe, A. Yoshida, K. Nagao
    • Journal Title

      Journal of Oleo Science

      Volume: 68 Issue: 2 Pages: 193-202

    • DOI

      10.5650/jos.ess18214

    • NAID

      130007588527

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice2018

    • Author(s)
      Hamajima Hiroshi、Tanaka Masaru、Miyagawa Miyuki、Sakamoto Mayuko、Nakamura Tsuyoshi、Yanagita Teruyoshi、Nishimukai Megumi、Mitsutake Susumu、Nakayama Jiro、Nagao Koji、Kitagaki Hiroshi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: - Issue: 8 Pages: 1-9

    • DOI

      10.1080/09168451.2018.1562877

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolism of Natural Highly Unsaturated Fatty Acid, Tetracosahexaenoic Acid (24:6n-3), in C57BL/KsJ-<i>db</i>/<i>db</i> Mice2018

    • Author(s)
      N. Gotoh, K. Nagao, H. Ishida, K. Nakamitsu, K. Yoshinaga, T. Nagai, F. Beppu, H. Watanabe, T. Yanagita
    • Journal Title

      Journal of Oleo Science

      Volume: 67 Issue: 12 Pages: 1597-1607

    • DOI

      10.5650/jos.ess18167

    • NAID

      130007539110

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of <i>Trans</i> Fatty Acid Formation in Oil by Heating Using Model Compounds2018

    • Author(s)
      N. Gotoh, S. Kagino, K. Yoshinaga, H. Mizobe,T. Nagai, A. Yoshida, F. Beppu, K. Nagao
    • Journal Title

      Journal of Oleo Science

      Volume: 67 Issue: 3 Pages: 273-281

    • DOI

      10.5650/jos.ess17209

    • NAID

      130006407106

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of the Effect of <i>trans</i> Fatty Acid Isomers on Apolipoprotein A1 and B Secretion in HepG2 Cells2017

    • Author(s)
      K. Nagao, K. Yoshinaga, T. Nagai, H. Mizobe, A. Yoshida, F. Beppu, N. Gotoh
    • Journal Title

      Journal of Oleo Science

      Volume: 66 Issue: 10 Pages: 1175-1181

    • DOI

      10.5650/jos.ess17074

    • NAID

      130006110006

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats.2017

    • Author(s)
      K. Nagao, T. Jinnouchi, S. Kai, T. Yanagita
    • Journal Title

      J. Nutr. Biochem.

      Volume: 43 Pages: 151-155

    • DOI

      10.1016/j.jnutbio.2017.02.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model Mice2017

    • Author(s)
      K. Nagao, A. Matsumoto, S. Kai, T. Kayashima, T. Yanagita
    • Journal Title

      Journal of Oleo Science

      Volume: 66 Issue: 2 Pages: 161-169

    • DOI

      10.5650/jos.ess16145

    • NAID

      130005306124

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure.2016

    • Author(s)
      B. Shirouchi, K. Nagao, M. Umegatani, A. Shiraishi, Y.Morita, S. Kai, T. Yanagita, A. Ogawa, Y. Kadooka, M. Sato
    • Journal Title

      Britsh Journal of Nutrition

      Volume: 116 Issue: 3 Pages: 451-458

    • DOI

      10.1017/s0007114516002245

    • NAID

      120006536897

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese Traditional Dietary Fungus Koji Aspergillus Oryzae Functions as a Prebiotic for Blautia Coccoides through Glycosylceramide.2016

    • Author(s)
      H. Hamajima, H. Matsunaga, A. Fujikawa, T. Sato, S. Mitsutake, T. Yanagita, K. Nagao, J. Nakayama, H. Kitagaki
    • Journal Title

      SpringerPlus

      Volume: 5 Issue: 1

    • DOI

      10.1186/s40064-016-2950-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of soy peptide on lipid metabolism and energy expenditure.2016

    • Author(s)
      Yotsumoto H., K. Nagao, T. Yanagita
    • Journal Title

      西九州大学健康栄養学部紀要

      Volume: 47 Pages: 1-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Inositol improves obesity-induced fatty liver and hepatic injury in obese, diabetic db/db mice.2018

    • Author(s)
      N. Inoue, K. Nagao, T. Yanagita
    • Organizer
      The 3rd International Symposium on Rice Science in Global Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コレステノンのリンパ輸送動態2018

    • Author(s)
      王天昱、城内文吾、武山藍、中山恵理子、永尾晃治、佐藤匡央
    • Organizer
      平成30年度日本食品科学工学会西日本支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 拘束ストレス負荷マウスに対するローズマリー(Rosmarinus officinalis L.)葉抽出物の効果2018

    • Author(s)
      萱島知子、西岡果那、永尾晃治、柴田紗知、松原主典
    • Organizer
      日本家政学会九州支部第64回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質構造異性体とメタボリックシンドローム2017

    • Author(s)
      永尾晃治
    • Organizer
      第71回日本栄養・食糧学会大会シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] メタボ予防における佐賀県産品の可能性2017

    • Author(s)
      永尾晃治
    • Organizer
      「さがフード&コスメラボ」キックオフセミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Comparison of the effect of trans fatty acid isomers on apolipoprotein A1 and B secretion in HepG2 cells.2017

    • Author(s)
      K. Nagao, K. Yoshinaga, T. Nagai, H. Mizobe, A. Yoshida, F. Beppu, N. Gotoh
    • Organizer
      The Asian conference on Oleo Science 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distribution of trans fatty acid isomers in processed foods provided in Japanese market.2017

    • Author(s)
      K. Yoshinaga, Y. Katoh, H. Mizobe, T. Nagai, A. Yoshida, F. Beppu, K. Nagao, N. Gotoh
    • Organizer
      The Asian conference on Oleo Science 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distribution of trans fatty acid isomers in meat, butter, and milk derived from ruminants provided in Japanese market.2017

    • Author(s)
      N. Gotoh, S. Kagiono, K. Yoshinaga, H. Mizobe, T. Nagai, A. Yoshida, F. Beppu, K. Nagao
    • Organizer
      The Asian conference on Oleo Science 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristic of trans fatty acid isomers in liquid oil formed by heating.2017

    • Author(s)
      N. Gotoh, S. Kagiono, K. Yoshinaga, H. Mizobe, T. Nagai, A. Yoshida, F. Beppu, K. Nagao
    • Organizer
      The Asian conference on Oleo Science 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 日本の伝統発酵食品に含まれている麹グルコシルセラミド含量の解析2017

    • Author(s)
      酒谷真以、Ferdouse Jannatul、阪本真由美、浜島弘史、柘植圭介、西向めぐみ、柳田晃良、永尾晃治、光武進、北垣浩志
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
  • [Presentation] コレステロール代謝と食事2016

    • Author(s)
      永尾晃治
    • Organizer
      第118回食用加工油脂技術研究会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 食品の機能性について-佐賀の特産食材を中心に-2016

    • Author(s)
      永尾晃治
    • Organizer
      「食道楽さが」研修会
    • Place of Presentation
      佐賀
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 麹グルコシルセラミドの腸内細菌叢への影響2016

    • Author(s)
      藤川彩美、佐藤友哉、浜島弘史、柳田晃良、光武進、永尾晃治、中山二郎、北垣浩志
    • Organizer
      第68回日本生物工学会大会
    • Place of Presentation
      富山
    • Related Report
      2016 Research-status Report
  • [Presentation] ローズマリー成分カルノシン酸の摂取が拘束ストレス負荷マウスに与える影響2016

    • Author(s)
      畑中悠花、萱島知子、筆本悠希、柴田紗知、上野純弥、永尾晃治、松原主典
    • Organizer
      日本家政学会第68回全国大会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Research-status Report
  • [Presentation] Lactobacillus gasseri SBT2055摂取がラットのエネルギー代謝および糖代謝に及ぼす影響2016

    • Author(s)
      城内文吾、梅ヶ谷南、白石彩、森田有紀子、甲斐俊一、永尾晃治、柳田晃良、小川哲弘、門岡幸男、佐藤匡央
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      西宮
    • Related Report
      2016 Research-status Report
  • [Presentation] トランス脂肪酸異性体間の組織への蓄積と異化効率の違い2016

    • Author(s)
      別府史章、浅沼公晴、河村芳徳、永井利治、吉永和明、溝部帆洋、小島浩一、笠井聡、永尾晃治、久保篤史、神田穣太、後藤直宏
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      西宮
    • Related Report
      2016 Research-status Report
  • [Book] 粥状動脈硬化症2016

    • Author(s)
      永尾晃治,柳田晃良 他(戸田隆義編)
    • Total Pages
      354
    • Publisher
      アトムス
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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