| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated the possibility that, besides the multi-functionality derived from the lactoferrin (LF) itself, LF expressed behaviors in conjunction with other bioactive compounds. The proteins and peptides present in LF used as a reagent and food ingredient were examined using LC-MS/MS proteomic analysis. Impurities in LF were fractionated using multi-stage methods, including affinity chromatography and ion exchange chromatography, and their bioactivities were individually evaluated by in vitro and in vivo experiments. Several components that exhibit bioactive characteristics, including immunomodulating effects and iron delivery metabolism were present among the impurities. The multifunctional properties of LF were suggested to be due to some compounds interacted with LF.
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