| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we first confirmed whether Fish oil-containing high-fat diet (FOD) prevents diet-induced obesity. FOD significantly suppressed body weight gain compared to lard-containing high-fat diet (LD). Next, using Alzheimer's disease model mice (AD mice), the relationship between obesity and cognitive function was evaluated by a novel object recognition test. Body weight in LD-fed AD mice increased, and cognitive dysfunction also impaired than chow-fed AD mice. On the other hand, in FOD-fed AD mice, body weight gain and cognitive dysfunction were suppressed more than in LD-fed AD mice. These results suggest that improvement in obesity prevents cognitive dysfunction due to Alzheimer's disease.
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