| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We previously elucidated that protein deprivation increased 4E-BP1 level, leading to fatty liver in rats. In this study, we examined how the increase in 4E-BP1 contributes to lipid accumulation in rat liver under protein deprivation. Overexpression of 4E-BP1 in the liver did not change hepatic triglyceride (TG) level in rats, regardless of nutritional status, suggesting that the increase in 4E-BP1 by itself is insufficient to increase TG level in rat liver. We also found that 4E-BP1 is involved in the suppression of fatty acid oxidation, leading to the increase in TG level in rat liver under protein deprivation. These results suggest that 4E-BP1 could regulate not only translation but also lipid metabolism in rat liver.
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