| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The vitamin A metabolite retinoic acid suppressed the induction of IL-6-dependent IL-13 high-producing inflammatory helper T (Th) cells. CD4+ T cells that produce IL-13 specifically for oral antigens were induced in the mesenteric lymph nodes of vitamin A-deficient mice. We found a cell surface molecule that was expressed on IL-13 high-producing inflammatory Th cells but not on Th2 and Th9 cells. This molecule has been reported to be expressed on Th1 and Th17 cells, expression on IL-13-producing cells has not been reported. In the future, we aim to construct a new allergy treatment method targeting this molecule.
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