| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Molluscan smooth muscles comprising of adductor muscles are able to maintain the tension for long periods with little energy consumption. To elucidate a molecular mechanism of catch contraction, interaction among thin-filament associate proteins were analyzed using isothermal titration calorimetry (ITC). ITC revealed that calponin isoforms interacted with tropomyosin; twitchin, the regulator protein of catch contraction, was unable to interact with tropomyosin. These findings suggest that some thin-filament associated proteins are involved in the catch contraction.
|
