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Analysis of salivary predictors evaluating cancer chemoprevention by fucoxanthin

Research Project

Project/Area Number 16K07880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Terasaki Masaru  北海道医療大学, 薬学部, 講師 (10391195)

Co-Investigator(Kenkyū-buntansha) 武藤 倫弘  国立研究開発法人国立がん研究センター, 社会と健康研究センター, 室長 (30392335)
増田 園子  北海道医療大学, 薬学部, 教授 (90157206)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん化学予防 / がん幹細胞 / フコキサンチン / フコキサンチノール / カロテノイド / メタボローム / 代謝物 / 唾液 / 天然物化学
Outline of Final Research Achievements

Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin (Fx). Glycine and succinic acid were good prognostic indicators of apoptosis induction to colorectal cancer stem cells-like cells by FxOH. Fx administration delays occurrence of tumors in xenograft mice by colorectal cancer stem cells-like cells with an anti-tumor predictor of glycine. Salivary glycine was a significant predictor for the attenuation of tumor microenvironment formation by Fx in AOM/DSS mice. Fx-high wakame could prevent formation of the tumor microenvironment with a salivary predictor of glycine of the Fx-high wakame function.

Academic Significance and Societal Importance of the Research Achievements

本研究では、FxOHによるがん幹細胞のapoptosis誘導機序、及びこの効果と相関する代謝物における重要な結果を得た。また、Fx及びFx-highワカメによるマウス大腸がん化学予防効果と相関する唾液代謝物に関する結果を得た。これらの成果は、今後、海藻や他の食品によるがん予防研究へ応用可能である。また、唾液メタボロームは、タンパク質や遺伝子発現と共に、がん予防効果を判別する指標となる可能性が高い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (10 results)

  • [Journal Article] Salivary Glycine Is a Significant Predictor for the Attenuation of Polyp and Tumor Microenvironment Formation by Fucoxanthin in AOM/DSS Mice2019

    • Author(s)
      Terasaki Masaru、Masaka Saki、Fukada Chinami、Houzaki Mayu、Endo Tetsuya、Tanaka Takuji、Maeda Hayato、Miyashita Kazuo、Mutoh Michihiro
    • Journal Title

      In Vivo

      Volume: 33 Issue: 2 Pages: 365-374

    • DOI

      10.21873/invivo.11483

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells2019

    • Author(s)
      Tamura Shuya、Narita Takumi、Fujii Gen、Miyamoto Shingo、Hamoya Takahiro、Kurokawa Yurie、Takahashi Maiko、Miki Kouhei、Matsuzawa Yui、Komiya Masami、Terasaki Masaru、Yano Tomohiro、Mutoh Michihiro
    • Journal Title

      Genes and Environment

      Volume: 41 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s41021-018-0116-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terasaki M, Iida T, Kikuchi F, Tamura K, Endo T, Kuramitsu Y, Tanaka T, Maeda H, Miyashita K, Mutoh M.2019

    • Author(s)
      Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice.
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 64 Pages: 198-205

    • DOI

      10.1016/j.jnutbio.2018.10.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CUB domain-containing protein 1 (CDCP1) was down-regulated by active hexose-correlated compound in human pancreatic cancer cells.2018

    • Author(s)
      Kuhara K, Tokuda K, Kitagawa T, Baron B, Tokunaga M, Harada K, Terasaki M, Uehara O, Ohta T, Takai R, Hamada J, Kobayashi M, Shimo T, Nagayasu H, Kuramitsu Y.
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 11 Pages: 6107-6111

    • DOI

      10.21873/anticanres.12961

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells.2018

    • Author(s)
      Terasaki M, Mima M, Kudoh S, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M.
    • Journal Title

      Oncology Reports

      Volume: 印刷中 Pages: 414-424

    • DOI

      10.3892/or.2018.6398

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glycine Is a Predictor for a Suppressive Effect of Fucoxanthinol on Colonosphere Formation Under Hypoxia.2018

    • Author(s)
      Terasaki M, Ogawa Y, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M.
    • Journal Title

      Anticancer Research

      Volume: 38 Pages: 2169-2179

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine2018

    • Author(s)
      Terasaki M, Matsumoto N, Hashimoto R, Endo T, Maeda H, Hamada J, Osada K, Miyashita K, Mutoh M
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 印刷中

    • NAID

      130007542258

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation2017

    • Author(s)
      Masaru Terasaki, Hayato Maeda, Kazuo Miyashita, Takuji Tanaka, Shingo Miyamoto and Michihiro Mutoh
    • Journal Title

      Journal fo Clinical Biochemistry and Nutrition

      Volume: 印刷中

    • NAID

      130006847660

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Induction of anoikis in human colorectal cancer cells by fucoxanthinol2017

    • Author(s)
      Masaru Terasaki, Hayato Maeda, Kazuo Miyashita and Michihiro Mutoh
    • Journal Title

      Nutrition and Cancer

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ヒト大腸がん由来細胞におけるFucoxanthiolとNF-κB阻害剤の共処理によるapoptosis誘導2018

    • Author(s)
      成田匠、田村秀哉、寺崎将、藤井元、小宮雅美、鱧屋隆博、黒川友里絵、高橋麻衣子、松澤優衣、三木洸平、武藤倫弘
    • Organizer
      日本がん予防学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] FucoxanthiolとNF-κB阻害剤の同時処理によるapoptosis増強作用2018

    • Author(s)
      三木洸平、田村秀哉、成田匠、寺崎将、藤井元、小宮雅美、鱧屋隆博、黒川友里絵、高橋麻衣子、松澤優衣、武藤倫弘、十島二郎
    • Organizer
      アグリ・バイオ公開シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] コキサンチンによる大腸がん幹細胞様細胞由来腫瘍発症抑制効果の指標となる唾液代謝物2018

    • Author(s)
      松本直也, 橋本龍一, 遠藤哲也, 寺崎 将
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] フコキサンチノールはがん幹細胞様細胞の腫瘍形成とスフィア形成を弱める2017

    • Author(s)
      寺崎 将, 武藤倫弘
    • Organizer
      日本薬学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Fucoxanthinolによる大腸がん細胞アノイキス誘導作用機序の解明2017

    • Author(s)
      小笠未遥、河野あやめ、遠藤哲也、寺崎 将
    • Organizer
      日本薬学北海道支部第144回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗がん剤によるがん幹細胞様細胞形成抑制機序を予測する代謝物の解析2017

    • Author(s)
      奥村美佑、鎌田渓奈、遠藤哲也、寺崎 将
    • Organizer
      日本薬学北海道支部第144回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 低酸素環境がん幹細胞におけるFucoxanthinolの代謝制御機構の解明2017

    • Author(s)
      小川ゆう姫、遠藤哲也、寺崎 将
    • Organizer
      日本薬学北海道支部第144回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 代謝物プロファイルに基づく大腸がん幹細胞におけるFucoxanthinolのEMT抑制効果の解析2017

    • Author(s)
      美馬雅俊、工藤里紀、遠藤哲也、寺崎 将
    • Organizer
      日本薬学北海道支部第144回例会
    • Related Report
      2017 Research-status Report
  • [Presentation] 1)ヒト大腸がん由来細胞に対するFucoxanthinとNF-κB阻害剤の併用によるアポトーシス誘導について2017

    • Author(s)
      田村秀哉、寺崎将、藤井 元、宮本真吾、小宮雅美、鱧屋隆博、黒川友理絵、高橋麻衣子、矢野友啓、武藤倫弘
    • Organizer
      第24回日本がん予防学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Metabolic markers related to suppression of epithelial-mesenchymal transition in cancer stem cells by fucoxanthinol2017

    • Author(s)
      Masaru Terasaki, Jun-ichi Hamada and Michihiro Mutoh
    • Organizer
      第76会日本癌学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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