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Study on the regulation of pituitary function in chicken by adipokine, leptin

Research Project

Project/Area Number 16K07983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionIbaraki University

Principal Investigator

Ohkubo Takeshi  茨城大学, 農学部, 教授 (70233070)

Research Collaborator NAMEKAWA Shoko  
SHAIKAT Amir H.  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsレプチン / ニワトリ / 下垂体 / 卵巣 / 家禽 / シグナル伝達
Outline of Final Research Achievements

In this study, we investigated the effects of leptin on the expression of pituitary hormone gene and the functional development of ovaries in chicken. The mRNA expression of pituitary hormones was differentially regulated by leptin on age, strain and so on. This leptin dependent mRNA expression was suggested to be coordinately regulated by direct action to pituitary gland and indirect action through hypothalamus. Furthermore, it was revealed that leptin acts on the hypothalamus-pituitary-gonad axis in an age specific manner to develop the ovarian function in juvenile chick.

Academic Significance and Societal Importance of the Research Achievements

鳥類におけるレプチンの生理機能については未だ十分には明らかにされていないが、レプチンがニワトリ下垂体へ作用することにより、成長や生殖などの生理反応を制御する可能性を見出したことは、今後の家禽内分泌学の進展に寄与するものである。特に、レプチンが幼若期のニワトリ卵巣の機能発達に影響を与えることを示した成果は、成長期の栄養制御が、性成熟の早期化による産卵成績の改善に繋がる可能性を示すものであり、学術的な価値は非常に高い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results)

  • [Int'l Joint Research] University of Arkansas(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Arkansas(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Determination of Polymorphisms in Pituitary Genes of the Native Afghani Naked Neck Chicken2019

    • Author(s)
      Ahmadi S, Takeda M, Ohkubo T
    • Journal Title

      Journal of Poultry Science

      Volume: 印刷中

    • NAID

      130007733294

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMP-activated protein kinase mediates the effect of leptin on avian autophagy in a tissue-specific manner2018

    • Author(s)
      Piekarski A, Nagarajan G, Ishola P, Flees J, Greene E, Kuenzel W, Ohkubo T, Helena Maier H, Bottje W, Cline M, Dridi S
    • Journal Title

      Frontiers in Physiology

      Volume: 印刷中 Pages: 541-541

    • DOI

      10.3389/fphys.2018.00541

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene expression profiling in embryonic chicken ovary during asymmetric development.2018

    • Author(s)
      Shaikat AH, Namekawa S, Ahmadi S, Takeda M and Ohkubo T
    • Journal Title

      Animal Science Journal

      Volume: 89 Issue: 4 Pages: 688-694

    • DOI

      10.1111/asj.12979

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Intracerebroventricular administration of leptin induces hepatic autophagy in chickens through AMPK pathway2018

    • Author(s)
      Greene E, Flees J, Bottje W, Ohkubo T, Maier H, Cline M, Dridi S
    • Organizer
      Poultry Science Association 107th Annual Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neuroendocrine regulation of avian hypothalamic autophagy by leptin.2018

    • Author(s)
      Flees J, Greene E, Kuenzel W, Bottje W, Ohkubo T, Maier H, Cline M, and Dridi S
    • Organizer
      Poultry Science Association 107th Annual Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] トランスサイレチン及びプロラクチン放出ペプチド mRNA 発現に対する短期絶食の影響2018

    • Author(s)
      武田未紗、大久保武
    • Organizer
      日本家禽学会2018年度秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Does leptin have a role in asymmetrical development of chicken ovary2017

    • Author(s)
      Shaikat Amir, Namekawa Shoko, Ahmadi Sadequllah, Takeda Misa, Ohkubo takeshi
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] アフガニスタン在来の Naked Neck のおけるプロラクチン及び Pit-1 遺伝子の遺伝子多型2017

    • Author(s)
      サデクラー アハマディ、大久保武
    • Organizer
      日本家禽学会2017年度春季大会
    • Place of Presentation
      神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] レプチンはニワトリヒナの卵巣のレプチン受容体、FSH 受容体、アロマターゼ及びアポト ーシスマーカーの発現を制御する。2017

    • Author(s)
      Amir Hossan Shaikat、大久保武
    • Organizer
      日本家禽学会2017年度春季大会
    • Place of Presentation
      神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] ウコッケイ視床下部における抱卵行動関連遺伝子の発現2017

    • Author(s)
      武田未紗、大久保武
    • Organizer
      日本家禽学会2017年度春季大会
    • Place of Presentation
      神戸大学
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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