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Studies of roles of inflammatory bioactive molecules on feeding regulation in chicks

Research Project

Project/Area Number 16K07991
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionEhime University

Principal Investigator

Tachibana Tetsuya  愛媛大学, 農学研究科, 准教授 (80346832)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsニワトリヒナ / 摂食行動 / 炎症性物質 / 栄養・飼養 / 畜産学 / 行動学 / 生理学
Outline of Final Research Achievements

The present study revealed that intracerebroventricular or intraperitoneal injection of interleukin-1β, tumor-necrosis factor-like cytokine-1A, prostaglandin E2 (PGE2), PGF2α and PGD2 decreased food intake in chicks. In addition, the injection of IL6, IL8, interferon-α (IFNα) and IFNγ, which suppress feeding behavior in rodents, had no effect on food intake in chicks. Intraperitoneal injection of lipopolysaccharide, which is a component of Gram-negative bacteria, and poly I:C, which is a synthetic double-stranded RNA suppressed feeding behavior with induction of gene expression of cytokines and PGs noted above. These results suggested that these cytokines and PGs would be related to anorexia inducec by infection of bacteria and virus in chicks.

Academic Significance and Societal Importance of the Research Achievements

病原性微生物の感染により、ニワトリは食欲不振に陥り、さらにはその生産性が低下する。この食欲不振には免疫に関わる炎症性物質が関わると考え、本研究ではニワトリヒナの摂食を抑制する炎症性物質の探索を進め、いくつかの炎症性物質がニワトリの摂食を抑制することを明らかにした。この成果は、ニワトリの摂食調節機構の解明を進めるものであるとともに、ニワトリの免疫系の解明に有用な情報を与えることができるものである。本研究の成果を基礎として今後の研究の発展させることで、感染時の食欲不振に伴う生産性の低下の防止に寄与できると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Physiological responses to central and peripheral injection of polyinosinic-polycytidylic acid in chicks.2019

    • Author(s)
      Tachibana T, Ishimaru Y, Takeda K, Khan MSI, Makino R, Cline MA.
    • Journal Title

      British Poultry Science

      Volume: 60 Issue: 1 Pages: 64-70

    • DOI

      10.1080/00071668.2018.1547361

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of central injection of tumor-necrosis factor-like cytokine 1A and interferons on food intake in chicks.2018

    • Author(s)
      Tachibana T, Ishimaru Y, Makino R, Khan MSI, Cline MA
    • Journal Title

      Physiology & Behavior

      Volume: 194 Pages: 199-204

    • DOI

      10.1016/j.physbeh.2018.05.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physiological response to central and peripheral injection of prostaglandin D2 in chicks.2018

    • Author(s)
      Tachibana T, Nakai Y, Makino R, Khan MSI, Cline MA.
    • Journal Title

      Prostaglandins & Other Lipid Mediators

      Volume: 137 Pages: 46-51

    • DOI

      10.1016/j.prostaglandins.2018.06.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible role of central interleukins on the anorexigenic effect of lipopolysaccharide in chicks.2017

    • Author(s)
      Tachibana T, Kodama T, Yamane S, Makino R, Khan SI, Cline MA.
    • Journal Title

      British Poultry Science

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of central and peripheral injection of prostaglandin E2 and F2α on feeding and the crop-emptying rate in chicks.2017

    • Author(s)
      Tachibana T, Nakai Y, Makino R, Khan MSI, Cline MA.
    • Journal Title

      Prostaglandins and Lipid Mediators

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] インターフェロンとTL1Aがニワトリヒナの摂食行動に与える影響2017

    • Author(s)
      74.石丸蓉子、牧野良輔、モハメド シャキル イスラム カーン、橘哲也
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] プロスタグランジンの中枢および末梢投与がニワトリヒナの摂食行動に与える影響2016

    • Author(s)
      中井康愛、牧野良輔、モハメド シャキル イスラム カーン、橘哲也
    • Organizer
      第40回鳥類内分泌研究会
    • Place of Presentation
      ホテルメルパルク松山(愛媛県松山市)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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