| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The objective of the present study is to elucidate the adaptive mechanism of waterfowl-origin avian influenza viruses to chicken. Most HA subtypes of avian influenza viruses propagated by chicken embryonic trachea organ culture(TOC). After serial passage of an H7 and two H9 subtype viruses in TOC, mutations were commonly introduced to NP genes of variants with increased ability to propagate in TOC, suggesting the relation of NP function to adaptation of influenza viruses to chicken respiratory epithelial cells. However, no chickens were infected with these variants by experimental inoculation. It was suggested that additional factors may be required for wild waterfowl-derived avian influenza viruses to adapt to poultry chicken.
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