| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Canstatin is a cleaved fragment of type IV collagen α2 chain, which is a component of basement membrane surrounding cardiomyocytes. This project aimed to clarify the pathophysiological role and regulatory mechanism of canstatin in heart. It has been demonstrated that canstatin inhibits hypoxia-induced apoptosis in cardiomyoblasts and regulates cellular functions of myofibroblasts and ion channel activity of ventricular myocytes. It has been also revealed that canstatin exerts cardioprotective effects on experimental models of cardiac disease. Further, mechanism of decrease in canstatin expression in myocardial infarction was clarified.
This study suggested that canstatin is an endogenous bioactive molecule working cardioprotectively. Based on the results of this study, it is expected that development of novel strategies for cardiac disease treatment targeting canstatin will progress.
|
