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Pathogenicity of a novel bunyavirus STB virus

Research Project

Project/Area Number 16K08041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Shimojima Masayuki  国立感染症研究所, ウイルス第一部, 室長 (10422411)

Co-Investigator(Kenkyū-buntansha) 谷口 怜  国立感染症研究所, ウイルス第一部, 主任研究官 (60734465)
渡辺 俊平  国立感染症研究所, ウイルス第一部, 研究員 (10621401)
Research Collaborator Sugimoto Satoko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords未知の微生物 / ウイルス / 病原性 / ナイロウイルス / STB/ISKウイルス / リアソータント / 日本で分離 / STBウイルス / ISKウイルス / 病原性の比較 / 感染受容体 / 獣医学
Outline of Final Research Achievements

Issyk-Kul fever in Central Asia is caused by a sub-species of Keterah orthonairovirus, Issyk-Kul virus (ISK virus). Recently, in Japan, a novel sub-species of the virus, Soft tick bunyavirus (STB virus) was isolated. STB virus had potential to cause a disease in humans. Through in vitro and in vivo experiments, however, apparent differences in in vitro tropism and in vivo pathogenicity between the two viruses. Combined with epidemiological information, the results indicated that STB virus did not cause a disease in a large population in Japan.

Academic Significance and Societal Importance of the Research Achievements

世の中にはいまだ知られていない微生物が多く存在すると考えられる。本研究ではそのような微生物に該当する(していた)Soft tick bunyavirusについて、人に病気を起こしうるものか実験から推測したものである。近年の解析技術の進歩により新たな微生物は次々と発見されており、本研究のように病気を起こしうるかどうかそれぞれについて調べる必要がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (42 results)

All 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (14 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 14 results,  Open Access: 13 results,  Acknowledgement Compliant: 2 results) Presentation (25 results)

  • [Int'l Joint Research] Public Health England/MRC-University of Glasgow(United Kingdom)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of the Philippines(Philippines)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Addis Ababa Sci Technol Univ(Ethiopia)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF-α Antibody.2018

    • Author(s)
      2.Hirosaki H, Maeda Y, Shimojima M, Maeda K, Iwata H, Takeyoshi M.
    • Journal Title

      Immunol Invest.

      Volume: 20 Issue: 5 Pages: 1-10

    • DOI

      10.1080/08820139.2018.1549067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration2018

    • Author(s)
      Tani Hideki、Komeno Takashi、Fukuma Aiko、Fukushi Shuetsu、Taniguchi Satoshi、Shimojima Masayuki、Uda Akihiko、Morikawa Shigeru、Nakajima Nozomi、Furuta Yousuke、Saijo Masayuki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: e0206416-e0206416

    • DOI

      10.1371/journal.pone.0206416

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seroprevalence of severe fever with thrombocytopenia syndrome (SFTS) virus antibodies in humans and animals in Ehime prefecture, Japan, an endemic region of SFTS2018

    • Author(s)
      Kimura Toshiya、Fukuma Aiko、Shimojima Masayuki、Yamashita Yasutaka、Mizota Fumi、Yamashita Mayumi、Otsuka Yuka、Kan Miki、Fukushi Shuetsu、Tani Hideki、Taniguchi Satoshi、Ogata Momoko、Kurosu Takeshi、Morikawa Shigeru、Saijo Masayuki、Shinomiya Hiroto
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 24 Issue: 10 Pages: 802-806

    • DOI

      10.1016/j.jiac.2018.06.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reemergence of Reston ebolavirus in Cynomolgus Monkeys, the Philippines, 2015.2018

    • Author(s)
      Demetria C, Smith I, Tan T, Villarico D, Simon EM, Centeno R, Tachedjian M, Taniguchi S, Shimojima M, Miranda NLJ, Miranda ME, Rondina MMR, Capistrano R, Tandoc A 3rd, Marsh G, Eagles D, Cruz R, Fukushi S.
    • Journal Title

      Emerg Infect Dis.

      Volume: 24 Issue: 7 Pages: 1285-1291

    • DOI

      10.3201/eid2407.171234

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RLRs and TLRs Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in an SFTSV Infection Mouse Model2018

    • Author(s)
      Yamada S, Shimojima M, Narita R, Tsukamoto Y, Kato H, Saijo M, Fujita T
    • Journal Title

      J Virol

      Volume: 印刷中 Issue: 13

    • DOI

      10.1128/jvi.02246-17

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Caffeic acid, a coffee-related organic acid, inhibits infection by severe fever with thrombocytopenia syndrome virus in vitro2018

    • Author(s)
      Ogawa M, Shirasago Y, Ando S, Shimojima M, Saijo M, Fukasawa M
    • Journal Title

      J Infect Chemother

      Volume: 印刷中 Issue: 8 Pages: 597-601

    • DOI

      10.1016/j.jiac.2018.03.005

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of antibody to severe fever with thrombocytopenia syndrome virus (SFTSV) in blood samples donated in a SFTS-endemic area in Japan.2018

    • Author(s)
      8.Matsumoto C, Shinohara N, Furuta RA, Tanishige N, Shimojima M, Matsubayashi K, Nagai T, Tsubaki K, Satake M.
    • Journal Title

      Vox Sang.

      Volume: 113 Issue: 3 Pages: 297-299

    • DOI

      10.1111/vox.12629

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus2018

    • Author(s)
      Suda Y, Chamberlain J, Dowall S, Saijo M, Horimoto T, Hewson R, Shimojima M
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 71 Issue: 3 Pages: 205-208

    • DOI

      10.7883/yoken.JJID.2017.354

    • NAID

      130006743921

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA2018

    • Author(s)
      Fukushi S, Fukuma A, Kurosu T, Watanabe S, Shimojima M, Shirato K, Iwata-Yoshikawa N, Nagata N, Ohnishi K, Ato M, Melaku SK, Sentsui H, Saijo M
    • Journal Title

      J Virol Methods

      Volume: 251 Pages: 22-29

    • DOI

      10.1016/j.jviromet.2017.10.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV2017

    • Author(s)
      Egawa K, Shimojima M, Taniguchi S, Nagata N, Tani H, Yoshikawa T, Kurosu T, Watanabe S, Fukushi S, Saijo M
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 11(12) Issue: 12 Pages: e0006076-e0006076

    • DOI

      10.1371/journal.pntd.0006076

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heparan sulfate proteoglycan is an important attachment factor for cell entry of Akabane and Schmallenberg viruses2017

    • Author(s)
      Murakami S, Takenaka-Uema A, Kobayashi T, Kato K, Shimojima M, Palmarini M, Horimoto T
    • Journal Title

      J Virol

      Volume: 91(15) Issue: 15

    • DOI

      10.1128/jvi.00503-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines.2017

    • Author(s)
      Taniguchi S, Maeda K, Horimoto T, Masangkay JS, Puentespina Jr R., Eres E, et al.
    • Journal Title

      Arch Virol

      Volume: - Issue: 6 Pages: 1529-1539

    • DOI

      10.1007/s00705-017-3251-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A neutralization assay with a severe fever with thrombocytopenia syndrome virus strain that makes plaques in inoculated cells.2017

    • Author(s)
      Taniguchi S, Fukuma A, Tani H, Fukushi S, Saijo M, Shimojima M.
    • Journal Title

      J Virol Methods.

      Volume: 244 Pages: 4-10

    • DOI

      10.1016/j.jviromet.2017.01.005

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.2016

    • Author(s)
      Suda Y, Fukushi S, Tani H, Murakami S, Saijo M, Horimoto T, Shimojima M.
    • Journal Title

      Arch Virol.

      Volume: 161 Issue: 6 Pages: 1447-54

    • DOI

      10.1007/s00705-016-2803-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] コンゴ民主共和国の国立生物医学研究所での検査体制とバイオセーフティ2018

    • Author(s)
      下島昌幸
    • Organizer
      第18回日本バイオセーフティ学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Protection of mice from a lethal challenge with SFTS virus by immunization with a novel recombinant LC16m8 expressing SFTS virus genes.2018

    • Author(s)
      Tomoki Yoshikawa,Satoshi Taniguchi,Hirofumi Kato,Hikaru Fujii,Miho Shibamura,Shumpei Watanabe,Kazutaka Egawa,Takuya Inagaki,Satoko Sugimoto,Supranee Phanthanawiboon,Shizuko Harada,Takeshi Kurosu,Shuetsu Fukushi,Masayuki Shimojima,Souichi Yamada,Shigeru Morikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Re-emergence of Reston Ebola virus in Cynomolgus monkeys in the Philippines, 2015.2018

    • Author(s)
      Shuetsu Fukushi,Satoshi Taniguchi,Shumpei Watanabe,Takeshi Kurosu,Tomoki Yoshikawa,Masayuki Shimojima,Shigeru Morikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fusogenic bat-borne orthoreovirus p17 protein regulates viral replication in a host-specific manner.2018

    • Author(s)
      Ryotaro Nouda,Takahiro Kawagishi,Yuta Kanai,Masayuki Shimojima,Masayuki Saijo,Yoshiharu Matsuura,Takeshi Kobayashi.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Study of the role of untranslated regions of the S segment genome of Lymphocytic Choriomeningitis Virus.2018

    • Author(s)
      Satoshi Taniguchi,Tomoki Yoshikawa,Masayuki Shimojima,Shuetsu Fukushi,Takeshi Kurosu,Hideki Tani,Fumihiro Kato,Takahiro Maeki,Shigeru Tajima,Chang-Kweng Lim,Shigeru Morikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] SFTS virus causes lethal severe fever with thrombocytopenia syndrome in Cats.2018

    • Author(s)
      Eun-Sil Park,Masayuki Shimojima,Tomoki Yoshikawa,Noriyo Nagata,Naoko Iwata,Shuetsu Fukushi,Shumpei Watanabe,Yasushi Ami,Takeshi Kurosu,Ken Maeda,Koichi Imaoka,Masayuki Saijo,Shigeru Morikawa.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hematopathogenesis of chimeric dengue mouse model.2018

    • Author(s)
      Supranee Phanthanawiboon,Takeshi Kurosu,Masayuki Shimojima,Shuetsu Fukushi,Tomoki Yoshikawa,Shumpei Watanabe,Tadaki Suzuki,Noriyo Nagata, Naoko Iwata-Yoshikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Inflammation amplifier plays a critical role in severe dengue hemorrhagic fever.2018

    • Author(s)
      Takeshi Kurosu,Daisuke Okuzaki,Shuetsu Fukushi,Masayuki Shimojima,Supranee Phanthanawiboon,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Therapeutic effects of human monoclonal antibodies to SFTS virus.2018

    • Author(s)
      Masayuki Shimojima,Taishi Onodera,Yoshimasa Takahashi,Satoko Sugimoto,Shuetsu Fukushi,Takeshi Kurosu,Tomoki Yoshikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nelson Bay reovirus σC body domain is associated with strain-specific differences in viral replication.2018

    • Author(s)
      Takahiro Kawagishi,Yuta Kanai,Yusuke Sakai,Ryotaro Nouda,Hideki Tani,Masayuki Shimojima,Masayuki Saijo,Yoshiharu Matsuura,Takeshi Kobayashi.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Caffeic acid, a coffee-related organic acid, inhibits infection with severe fever with thrombocytopenia syndrome virus.2018

    • Author(s)
      Motohiko Ogawa,Yoshitaka Shirasago,Shuji Ando,Masayuki Shimojima,Masayuki Saijo,Masayoshi Fukasawa.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Establishment of an animal model of Heartland virus infection and evaluation of the efficacy of ribavirin and T-705 in vitro and in vivo. The 66th Annual Meeting of the Japanese Society for Virology.2018

    • Author(s)
      Hikaru Fujii,Hideki Tani,Kazutaka Egawa,Satoshi Taniguchi,Tomoki Yoshikawa,Chang-Kweng Lim,Mutsuyo Takayama-Ito,Takahiro Maeki,Takeshi Kurosu,Shuetsu Fukushi,Masayuki Shimojima,Akihiko Uda,Shigeru Morikawa,Masayuki Saijo.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of pseudotyped vesicular stomatitis virus bearing the Heartland virus envelope protein.2018

    • Author(s)
      Miyuki Kimura,Kazutaka Egawa,Masayuki Shimojima,Hikaru Fujii,Hiroshi Yamada,Long Tan,Shigeru Morikawa,Masayuki Saijo,Hideki Tani.
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] 重症熱性血小板減少症候群SFTSの霊長類致死モデル2018

    • Author(s)
      下島昌幸、谷口怜、網康至、永田典代、福士秀悦、黒須剛、渡辺俊平、谷英樹、福間藍子、岩田奈織子、西條政幸
    • Organizer
      SFTS研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SFTSVおよびHRTV感染におけるリバビリンおよびファビピラビルの抗ウイルス効果の比較2018

    • Author(s)
      藤井ひかる、谷英樹、谷口怜、吉河智城、林昌宏、伊藤睦代、前木孝洋、黒須剛、福士秀悦、下島昌幸、宇田晶彦、米納孝、古田要介、森川茂、西條政幸
    • Organizer
      SFTS研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 重症熱性血小板減少症候群に対するファビピラビルの有効性と安全性の検討2018

    • Author(s)
      末盛浩一郎、東太一、山中篤志、姫路大輔、川村昌史、葉久貴司、大毛宏喜、谷口智宏、今滝修、高橋徹、石田正之、日高道弘、金子正彦、池田賢一、上国料千夏、垣花泰之、石丸敏之、竹中克斗、下島昌幸、河野茂、西條政幸、安川正貴
    • Organizer
      SFTS研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミニゲノムを用いたニパウイルス、バングラディシュ株の転写・複製活性の解析2018

    • Author(s)
      渡辺俊平、Glenn A. Marsh、黒須剛, 吉河智城, 福士秀悦, 加来義浩,下島昌幸,西條政幸
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ニパウイルス流行株における転写・複製活性の比較解析2018

    • Author(s)
      渡辺俊平、Glenn A. Marsh、黒須剛, 吉河智城, 福士秀悦, 加来義浩,下島昌幸,西條政幸
    • Organizer
      第33回中国四国ウイルス研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nelson bay orthoreovirus cell attachment protein σC determines strain-specific differences in viral infectivity and pathogenesis2017

    • Author(s)
      Kawagishi T, Kanai Y, Nouda R, Tani H, Shimojima M, Saijo M, Matsuura Y, Kobayashi T
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] The dynamics of disease progression in severe dengue2017

    • Author(s)
      Kurosu T, Okuzaki D, Limkittikul K, Shimojima M, Fukushi S, Watanabe S, Saijo M
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of competitive ELISA for detecting serologic responses to MERS-CoV using novel monoclonal antibodies against spike protein2017

    • Author(s)
      Fukushi S, Kurosu T, Watanabe S, Shimojima M, Shirato K, Matsuyama S, Yoshikawa-Iwata N, Nagata N, Ohnishi K, Ato M, Sentsui H, Saijo M
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] A non-human primate model for severe fever with thrombocytopenia syndrome SFTS2017

    • Author(s)
      Shimojima M, Taniguchi S, Ami Y, Nagata N, Fukushi S, Kurosu T, Watanabe S, Tani H, Fukuma A, Iwata-Yoshikawa N, Saijo M
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] A host cell membrane protein interacts with HSV-1 gE and promotes viral cell-to-cell spread2017

    • Author(s)
      Watanabe M, Arii J, Shimojima M, Kato A, Kawaguchi Y
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2017 Research-status Report
  • [Presentation] Pathogenicity of human-origin Pteropine orthoreovirus (PRV) and bat-origin PRV in BALB/c mice.2016

    • Author(s)
      Egawa K, Shimojima M, Taniguchi S, Nagata N, Tani H, Yoshikawa T, Kurosu T, Fukushi S, Saijo M.
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology.
    • Place of Presentation
      札幌
    • Related Report
      2016 Research-status Report
  • [Presentation] BALB/cマウスにおけるヒト由来およびコウモリ由来プテロパインオルソレオウイルスの病原性解析2016

    • Author(s)
      江川和孝、下島昌幸、谷口怜、永田典代、谷英樹、黒須剛、吉河智城、福士秀悦、西條政幸
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      藤沢
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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