Pathogenicity of a novel bunyavirus STB virus
Project/Area Number |
16K08041
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
谷口 怜 国立感染症研究所, ウイルス第一部, 主任研究官 (60734465)
渡辺 俊平 国立感染症研究所, ウイルス第一部, 研究員 (10621401)
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Research Collaborator |
Sugimoto Satoko
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 未知の微生物 / ウイルス / 病原性 / ナイロウイルス / STB/ISKウイルス / リアソータント / 日本で分離 / STBウイルス / ISKウイルス / 病原性の比較 / 感染受容体 / 獣医学 |
Outline of Final Research Achievements |
Issyk-Kul fever in Central Asia is caused by a sub-species of Keterah orthonairovirus, Issyk-Kul virus (ISK virus). Recently, in Japan, a novel sub-species of the virus, Soft tick bunyavirus (STB virus) was isolated. STB virus had potential to cause a disease in humans. Through in vitro and in vivo experiments, however, apparent differences in in vitro tropism and in vivo pathogenicity between the two viruses. Combined with epidemiological information, the results indicated that STB virus did not cause a disease in a large population in Japan.
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Academic Significance and Societal Importance of the Research Achievements |
世の中にはいまだ知られていない微生物が多く存在すると考えられる。本研究ではそのような微生物に該当する(していた)Soft tick bunyavirusについて、人に病気を起こしうるものか実験から推測したものである。近年の解析技術の進歩により新たな微生物は次々と発見されており、本研究のように病気を起こしうるかどうかそれぞれについて調べる必要がある。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Reemergence of Reston ebolavirus in Cynomolgus Monkeys, the Philippines, 2015.2018
Author(s)
Demetria C, Smith I, Tan T, Villarico D, Simon EM, Centeno R, Tachedjian M, Taniguchi S, Shimojima M, Miranda NLJ, Miranda ME, Rondina MMR, Capistrano R, Tandoc A 3rd, Marsh G, Eagles D, Cruz R, Fukushi S.
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Journal Title
Emerg Infect Dis.
Volume: 24
Issue: 7
Pages: 1285-1291
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA2018
Author(s)
Fukushi S, Fukuma A, Kurosu T, Watanabe S, Shimojima M, Shirato K, Iwata-Yoshikawa N, Nagata N, Ohnishi K, Ato M, Melaku SK, Sentsui H, Saijo M
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Journal Title
J Virol Methods
Volume: 251
Pages: 22-29
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV2017
Author(s)
Egawa K, Shimojima M, Taniguchi S, Nagata N, Tani H, Yoshikawa T, Kurosu T, Watanabe S, Fukushi S, Saijo M
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Journal Title
PLoS Negl Trop Dis
Volume: 11(12)
Issue: 12
Pages: e0006076-e0006076
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Development of competitive ELISA for detecting serologic responses to MERS-CoV using novel monoclonal antibodies against spike protein2017
Author(s)
Fukushi S, Kurosu T, Watanabe S, Shimojima M, Shirato K, Matsuyama S, Yoshikawa-Iwata N, Nagata N, Ohnishi K, Ato M, Sentsui H, Saijo M
Organizer
The 65th Annual Meeting of the Japanese Society for Virology
Related Report
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[Presentation] A non-human primate model for severe fever with thrombocytopenia syndrome SFTS2017
Author(s)
Shimojima M, Taniguchi S, Ami Y, Nagata N, Fukushi S, Kurosu T, Watanabe S, Tani H, Fukuma A, Iwata-Yoshikawa N, Saijo M
Organizer
The 65th Annual Meeting of the Japanese Society for Virology
Related Report
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