Endosymbiotic bacteria that affect host meiosis
| Project/Area Number |
16K08106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Insect science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
KAGEYAMA Daisuke 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 上級研究員 (60401212)
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| Co-Investigator(Kenkyū-buntansha) |
佐原 健 岩手大学, 農学部, 教授 (30241368)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ボルバキア / 共生細菌 / 減数分裂 / マイオティックドライブ / 染色体 / 性決定 |
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| Outline of Final Research Achievements |
Wolbachia is known to manipulate the insect hosts by various ways for their own benefit. Our study revealed a novel type of host manipulation by Wolbachia. Female Eurema mandarina butterflies infected with Wolbachia strain wFem produce all-female offspring by crossing with males. These offspring females, as well as their mothers, were revealed to have Z0 karyotype (sex chromosome constitution). Wolbachia was found to disrupt the maternal inheritance of Z chromosomes. Circumstantial evidence support the possibility that Wolbachia digests maternal Z chromosome during female meiosis. These results can lead to the better understanding of reproduction and endosymbiosis and basic contribution to future pest management strategies.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、今まで全く知られていなかった方法で微生物が昆虫の生殖システムを操作していることが明らかとなった。ボルバキアとよばれる細菌が、昆虫の性決定に影響を与えるだけでなく、性染色体の遺伝を妨げていることを示すことができた。さらにその仕組みとして、状況証拠をもとに、メスの減数分裂期に性染色体をまるごと消失させているという仮説を提示することができた。この成果は、発生学、進化生物学に新たな光を当てるだけでなく、生物の人工制御の可能性を予感させる内容であり、基礎的に重要なものである。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Functional crosstalk across IMD and Toll pathways: insight into the evolution of incomplete immune cascades.2019
Author(s)
Nishide, Y., Kageyama, D., Yokoi, K., Tanaka, H., Futahashi, R., Fukatsu T.
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Journal Title
Proceedings of the Royal Society B
Volume: 286
Issue: 1897
Pages: 20182207-20182207
DOI
Related Report
Peer Reviewed
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[Journal Article] Feminizing Wolbachia endosymbiont disrupts maternal sex chromosome inheritance in a butterfly species2017
Author(s)
Kageyama D, Ohno M, Sasaki T, Yoshido A, Konagaya T, Jouraku A, Kuwazaki S, Kanamori H, Katayose Y, Narita S, Miyata M, Riegler M, Sahara K
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Journal Title
Evolution Letters
Volume: 1
Issue: 5
Pages: 232-244
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 動物学の百科事典2018
Author(s)
公益社団法人日本動物学会
Total Pages
800
Publisher
丸善出版
ISBN
4621303090
Related Report
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