| Project/Area Number |
16K08141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | National Institute for Basic Biology (2017-2019)
Nagoya University (2016) |
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Principal Investigator |
Tsugane Mika 基礎生物学研究所, 共生システム研究部門, 特別協力研究員 (90625592)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞周期 / イネ / 核内倍加 / 発生・分化 / 発現制御 |
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| Outline of Final Research Achievements |
Plants produce polyploid cells by a unique cell cycle, endoreplication. However, in rice vegetative tissues, endoreplication is inhibited. We demonstrated that a mutant of cell-cycle related gene CYCA2 induced polyploid cells in leaves and roots of rice. Regulation mechanisms of CYCA2 seemed to be different between rice and other plants with polyploid cells produced by endoreplication. In rice, endoreplication was strictly repressed with several factors. Moreover, the results suggested that polyploidy is tissue specifically regulated and is dependent on plant developmental stages.
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| Academic Significance and Societal Importance of the Research Achievements |
核内倍加をする植物を用いた倍加の程度に影響する因子の研究報告は多くあるが、核内倍加を起こさないイネを材料として倍加の有無の決定に着目した研究はこれまでにない。本研究により、細胞分化と核内倍加の関連性が示唆されたことからも、今後はクロマチン構造に関わる制御機構の解明が鍵となることを示すことができた。イネが核内倍加を起こさない要因を明らかにすることができれば、倍加制御の仕組みだけではなく、倍加を起こす（起こさない）戦略を選んだ植物における倍加の役割を明らかにできる。
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