| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The target of this project was the development of new synthetic methods for the construction of carbocycles. Carbocycles are seen in the structure of clinical drugs and biologically active compounds.
We have developed our original chiral nickel catalyst which twists the coordinated molecule. With the use of this catalyst and its structural information, we achieved stereoselective construction of 6-membered ring. It was applied to the enantioselective synthesis of carbazole skeletons.
We developed the stereoselective construction of 5-membered ring by using chiral copper catalyst. We also achieved the indium-catalyzed 7-membered ring formation. 8-Membered ring construction was just developed by using ytterbium catalyst, and we are now preparing the manuscript for publication.
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