| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Toward total synthesis of antitumor saponin silaciloside E-1, synthesis of the A ring unit was accomplished. By incorporating the cyclic carbonate structure into the substrate, the key gold-catalyzed 6-endo cyclization of 1,6-enyne proceeded with perfect regioselectivity. An improved synthesis of CDE ring unit was also developed by exploiting the ring-contractive coupling reaction and the elimination reaction of the quaternary ammonium salt. As a result, the synthetic route was shorted by six steps.
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