Development of novel push-pull ethylene organocatalysts and their application to synthesis of medicines
| Project/Area Number |
16K08178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平島 真一 東京薬科大学, 薬学部, 講師 (80642264)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 有機触媒 / 不斉反応 / 有機化学 / 触媒・化学プロセス / 薬学 |
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| Outline of Final Research Achievements |
Asymmetric reactions using organocatalysts have attracted a great deal attention in green chemistry and are expected their application to synthesis of medicines. However, development of efficient organocatalysts is highly desirable due to low of catalytic activity. Therefore, we developed novel push-pull ethylene organocatalysts and achieved their application to various stereoselective reactions.
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| Academic Significance and Societal Importance of the Research Achievements |
環境負荷の大きい金属試薬や金属触媒を使用せずに，有機分子触媒を用いて，光学活性な中間体を合成する化学技術は，今後の医薬品合成に必要不可欠な方法論となりえます。また，医薬品中への金属の混入も起こりえないことからも，安心安全に臨床現場に医薬品を届ける化学技術です。近い将来，この度の研究助成金で開発された有機分子触媒および不斉反応によって得られた光学活性合成中間体から，医薬品が製造されることが大いに期待されます。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Design of Novel Hydrogen-bonding Donor Organocatalysts and Their Application to Asymmetric Direct Aldol Reaction2017
Author(s)
H. Akutsu, K. Nakashima, H. Yanai, A. Kotani, S. Hirashima, T. Yamamoto, R. Takahashi, A. Yoshida, Y. Koseki, H. Hakamata, T. Matsumoto, T. Miura
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Journal Title
Synlett
Volume: 28
Issue: 11
Pages: 1363-1367
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis of 2-hydroxymalonic acid derivatives via tandem oxidation and rearrangement by photo organic catalysis2016
Author(s)
Akifumi Okada, Yoshitomo Nagasawa, Tomoaki Yamaguchi, Eiji Yamaguchi, Akifumi Okada, Yoshitomo Nagasawa, Tomoaki Yamaguchi, Eij Yamaguchi, Norihiro Tada, Tsuyoshi Miura, Akichika Itoh
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Journal Title
RSC Adv.
Volume: 6
Issue: 48
Pages: 42596-42599
DOI
Related Report
Peer Reviewed
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