| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We developed two types of 3-aza-Cope-Mannich cascade reactions. Based on the ion-pair extraction using tetracyanocyclopentadienide (TCCP) salts, we first synthesized a complex quaternary vinyl ammonium salt which is a starting material of a 3-aza-Cope-Mannich reaction to afford Tricyclic alkaloid skeleton. Next, we examined a cascade reaction involving Gold catalyzed 5-exo-dig cyclization, 3-aza-Cope rearrangement of a spiro vinyl ammonium intermediate, and a Mannich reaction. We successfully obtained a tetracyclic compound including cephalotaxine skeleton. Further studies of the TCCP ion-pair extraction and studies toward the total synthesis of alkaloid natural products are ongoing in our laboratory based on the knowledges obtained by this project.
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